Electrochemiluminescent detection of methamphetamine and amphetamine

Jonathan McGeehan, Lynn Dennany

Research output: Contribution to journalSpecial issue

8 Citations (Scopus)

Abstract

Direct detection of amphetamine type stimulants (ATS) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. This contribution focuses on the electrochemical and photochemical properties of [Ru(bpy)3]2+ nafion composite films and their subsequent use for the detection of ATS in particular MA. Under optimised conditions, the response linearly increased with the concentration over the concentration range 50 pM <[MA]< 1 mM while an equivalent dynamic range was obtained for amphetamine with a correlation coefficient of 0.9903 and 0.9948 respectively. The ECL signal was monitored at ~620 nm, representing the λmax for the [Ru(bpy)3]2+ nafion composite films. This wavelength is shifted by approximately 15 nm compared to the photoexcited λmax for the same system. The modified films were formed by direct interaction with the electrode surface without the need for surface modification or chain linkers. This is a major advantage for the fabrication of any sensor as it reduces the synthesis times resulting in more economically and cheaper production costs. This technique is simple, rapid, selective and sensitive, and shows potential for the high-throughput quantitation of ATS as well as possibilities for adaptation with other techniques such as FIA or LC systems.
LanguageEnglish
Pages1-6
Number of pages6
JournalForensic Science International
Volume264
DOIs
Publication statusPublished - 5 Mar 2016

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Methamphetamine
Amphetamine
Electrochemical Techniques
Electrodes
Costs and Cost Analysis
Pharmaceutical Preparations
perfluorosulfonic acid
bis(bipyridyl)ruthenium(II)
tris(2,2'-bipyridine)ruthenium II

Keywords

  • electrochemiluminescence (ECL)
  • amphetamine-like drugs
  • electrochemical detection
  • ruthenium complexes

Cite this

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title = "Electrochemiluminescent detection of methamphetamine and amphetamine",
abstract = "Direct detection of amphetamine type stimulants (ATS) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. This contribution focuses on the electrochemical and photochemical properties of [Ru(bpy)3]2+ nafion composite films and their subsequent use for the detection of ATS in particular MA. Under optimised conditions, the response linearly increased with the concentration over the concentration range 50 pM <[MA]< 1 mM while an equivalent dynamic range was obtained for amphetamine with a correlation coefficient of 0.9903 and 0.9948 respectively. The ECL signal was monitored at ~620 nm, representing the λmax for the [Ru(bpy)3]2+ nafion composite films. This wavelength is shifted by approximately 15 nm compared to the photoexcited λmax for the same system. The modified films were formed by direct interaction with the electrode surface without the need for surface modification or chain linkers. This is a major advantage for the fabrication of any sensor as it reduces the synthesis times resulting in more economically and cheaper production costs. This technique is simple, rapid, selective and sensitive, and shows potential for the high-throughput quantitation of ATS as well as possibilities for adaptation with other techniques such as FIA or LC systems.",
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Electrochemiluminescent detection of methamphetamine and amphetamine. / McGeehan, Jonathan; Dennany, Lynn.

In: Forensic Science International, Vol. 264, 05.03.2016, p. 1-6.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - Electrochemiluminescent detection of methamphetamine and amphetamine

AU - McGeehan, Jonathan

AU - Dennany, Lynn

PY - 2016/3/5

Y1 - 2016/3/5

N2 - Direct detection of amphetamine type stimulants (ATS) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. This contribution focuses on the electrochemical and photochemical properties of [Ru(bpy)3]2+ nafion composite films and their subsequent use for the detection of ATS in particular MA. Under optimised conditions, the response linearly increased with the concentration over the concentration range 50 pM <[MA]< 1 mM while an equivalent dynamic range was obtained for amphetamine with a correlation coefficient of 0.9903 and 0.9948 respectively. The ECL signal was monitored at ~620 nm, representing the λmax for the [Ru(bpy)3]2+ nafion composite films. This wavelength is shifted by approximately 15 nm compared to the photoexcited λmax for the same system. The modified films were formed by direct interaction with the electrode surface without the need for surface modification or chain linkers. This is a major advantage for the fabrication of any sensor as it reduces the synthesis times resulting in more economically and cheaper production costs. This technique is simple, rapid, selective and sensitive, and shows potential for the high-throughput quantitation of ATS as well as possibilities for adaptation with other techniques such as FIA or LC systems.

AB - Direct detection of amphetamine type stimulants (ATS) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. This contribution focuses on the electrochemical and photochemical properties of [Ru(bpy)3]2+ nafion composite films and their subsequent use for the detection of ATS in particular MA. Under optimised conditions, the response linearly increased with the concentration over the concentration range 50 pM <[MA]< 1 mM while an equivalent dynamic range was obtained for amphetamine with a correlation coefficient of 0.9903 and 0.9948 respectively. The ECL signal was monitored at ~620 nm, representing the λmax for the [Ru(bpy)3]2+ nafion composite films. This wavelength is shifted by approximately 15 nm compared to the photoexcited λmax for the same system. The modified films were formed by direct interaction with the electrode surface without the need for surface modification or chain linkers. This is a major advantage for the fabrication of any sensor as it reduces the synthesis times resulting in more economically and cheaper production costs. This technique is simple, rapid, selective and sensitive, and shows potential for the high-throughput quantitation of ATS as well as possibilities for adaptation with other techniques such as FIA or LC systems.

KW - electrochemiluminescence (ECL)

KW - amphetamine-like drugs

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KW - ruthenium complexes

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