Abstract
| Language | English |
|---|---|
| Pages | 67874-67877 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 5 |
| Issue number | 83 |
| DOIs | |
| Publication status | Published - 31 Jul 2015 |
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Keywords
- recombinant antibodies
- cardiac biomarkers
- c-reactive proteins
Cite this
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Electrochemiluminescence platform for the detection of C-reactive proteins : application of recombinant antibody technology to cardiac biomarker detection. / O'Reilly, Emmet J.; Conroy, Paul J.; Hearty, Stephen; Keyes, Tia E.; O'Kennedy, Richard; Forster, Robert J.; Dennany, Lynn.
In: RSC Advances, Vol. 5, No. 83, 31.07.2015, p. 67874-67877.Research output: Contribution to journal › Article
TY - JOUR
T1 - Electrochemiluminescence platform for the detection of C-reactive proteins
T2 - RSC Advances
AU - O'Reilly, Emmet J.
AU - Conroy, Paul J.
AU - Hearty, Stephen
AU - Keyes, Tia E.
AU - O'Kennedy, Richard
AU - Forster, Robert J.
AU - Dennany, Lynn
PY - 2015/7/31
Y1 - 2015/7/31
N2 - This work exploits the high-affinity of recombinant antibodies and low background electrochemiluminescence (ECL) for cardiac-biomarker detection. The developed assay is capable of fg mL-1 detection limits as well as the detection of C-Reactive Protein (CRP) over a clinically relevant range. The assay demonstrated robust reproducibility, selectivity and stability while also highlighting a novel platform for detection of cardiac biomarkers at low concentrations.
AB - This work exploits the high-affinity of recombinant antibodies and low background electrochemiluminescence (ECL) for cardiac-biomarker detection. The developed assay is capable of fg mL-1 detection limits as well as the detection of C-Reactive Protein (CRP) over a clinically relevant range. The assay demonstrated robust reproducibility, selectivity and stability while also highlighting a novel platform for detection of cardiac biomarkers at low concentrations.
KW - recombinant antibodies
KW - cardiac biomarkers
KW - c-reactive proteins
U2 - 10.1039/C5RA08450D
DO - 10.1039/C5RA08450D
M3 - Article
VL - 5
SP - 67874
EP - 67877
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 83
ER -