Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol

Nicholas C. O. Tomkinson; Timothy M. Willson; Thomas A. Spencer; Jonathon S. Russell

Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol

Nicholas C. O. Tomkinson, Timothy M. Willson, Thomas A. Spencer, Jonathon S. Russell

Pure And Applied Chemistry

Research output: Contribution to conference › Other

Abstract

Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (1) have been developed starting from cholenic acid (2) or stigmasterol (3), both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate (4). This work permits prepn. of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor. [on SciFinder(R)]

Original language	English
Pages	OGRN-025
Publication status	Published - 1998
Event	216th National Meeting of the American Chemical Society - Boston, United States Duration: 23 Aug 1998 → 27 Aug 1998

Conference

Conference	216th National Meeting of the American Chemical Society
Country/Territory	United States
City	Boston
Period	23/08/98 → 27/08/98

Keywords

efficient
steroselective synthesis
25-epoxycholesterol

Cite this

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title = "Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol",

abstract = "Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (1) have been developed starting from cholenic acid (2) or stigmasterol (3), both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate (4). This work permits prepn. of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor. [on SciFinder(R)]",

keywords = "efficient, steroselective synthesis, 25-epoxycholesterol",

author = "Tomkinson, {Nicholas C. O.} and Willson, {Timothy M.} and Spencer, {Thomas A.} and Russell, {Jonathon S.}",

note = "CAPLUS AN 1998:530388(Conference; Meeting Abstract); 216th National Meeting of the American Chemical Society ; Conference date: 23-08-1998 Through 27-08-1998",

year = "1998",

language = "English",

pages = "OGRN--025",

}

TY - CONF

T1 - Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol

AU - Tomkinson, Nicholas C. O.

AU - Willson, Timothy M.

AU - Spencer, Thomas A.

AU - Russell, Jonathon S.

N1 - CAPLUS AN 1998:530388(Conference; Meeting Abstract)

PY - 1998

Y1 - 1998

N2 - Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (1) have been developed starting from cholenic acid (2) or stigmasterol (3), both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate (4). This work permits prepn. of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor. [on SciFinder(R)]

AB - Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (1) have been developed starting from cholenic acid (2) or stigmasterol (3), both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate (4). This work permits prepn. of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor. [on SciFinder(R)]

KW - efficient

KW - steroselective synthesis

KW - 25-epoxycholesterol

M3 - Other

SP - OGRN-025

T2 - 216th National Meeting of the American Chemical Society

Y2 - 23 August 1998 through 27 August 1998

ER -

Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol

Abstract

Conference

Keywords

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Cite this