Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

William J. Kerr; David M. Lindsay; Vipulkumar K. Patel; Muralikrishnan Rajamanickam

doi:10.1039/C5OB01849H

Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

William J. Kerr, David M. Lindsay, Vipulkumar K. Patel, Muralikrishnan Rajamanickam

Pure And Applied Chemistry

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Abstract

Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.

Original language	English
Pages (from-to)	10131-10135
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	40
DOIs	https://doi.org/10.1039/C5OB01849H
Publication status	Published - 21 Sept 2015

Keywords

ketones
kinetic enol phosphates
cyclohexanones

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10.1039/C5OB01849H

Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon-centredAccepted author manuscript, 3.37 MB
Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbonFinal published version, 227 KBLicence: CC BY 4.0

Cite this

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title = "Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases",

abstract = "Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.",

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AU - Kerr, William J.

AU - Lindsay, David M.

AU - Patel, Vipulkumar K.

AU - Rajamanickam, Muralikrishnan

PY - 2015/9/21

Y1 - 2015/9/21

N2 - Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.

AB - Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.

KW - ketones

KW - kinetic enol phosphates

KW - cyclohexanones

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2015/OB/C5OB01849H#!divAbstract

U2 - 10.1039/C5OB01849H

DO - 10.1039/C5OB01849H

M3 - Article

SN - 1477-0520

VL - 13

SP - 10131

EP - 10135

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 40

ER -

Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

Abstract

Keywords

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