Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

William J. Kerr, David M. Lindsay, Vipulkumar K. Patel, Muralikrishnan Rajamanickam

Research output: Contribution to journalArticle

2 Citations (Scopus)
56 Downloads (Pure)

Abstract

Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.
Original languageEnglish
Pages (from-to)10131-10135
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number40
DOIs
Publication statusPublished - 21 Sep 2015

Keywords

  • ketones
  • kinetic enol phosphates
  • cyclohexanones

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