Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.
- kinetic enol phosphates
Kerr, W. J., Lindsay, D. M., Patel, V. K., & Rajamanickam, M. (2015). Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases. Organic and Biomolecular Chemistry, 13(40), 10131-10135. https://doi.org/10.1039/C5OB01849H