Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model

Charitra N. Grama, Palla Suryanarayana, Madhoosudan A. Patil, Ganugula Raghu, Nagalla Balakrishna, M. N. V. Ravi Kumar, Geereddy Bhanuprakash Reddy

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Curcumin, the active principle present in the yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities. Previously we have reported that dietary curcumin delays diabetes-induced cataract in rats. However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin. In this study, we have administered curcumin encapsulated nanoparticles in streptozotocin (STZ) induced diabetic cataract model. Oral administration of 2 mg/day nanocurcumin was significantly more effective than curcumin in delaying diabetic cataracts in rats. The significant delay in progression of diabetic cataract by nanocurcumin is attributed to its ability to intervene the biochemical pathways of disease progression such as protein insolubilization, polyol pathway, protein glycation, crystallin distribution and oxidative stress. The enhanced performance of nanocurcumin can be attributed probably to its improved oral bioavailability. Together, the results of the present study demonstrate the potential of nanocurcumin in managing diabetic cataract.

LanguageEnglish
Article numbere78217
Number of pages8
JournalPLOS One
Volume8
Issue number10
DOIs
Publication statusPublished - 14 Oct 2013

Fingerprint

biodegradability
Curcumin
curcumin
cataract
nanoparticles
Nanoparticles
Cataract
Rats
animal models
bioavailability
Biological Availability
crystallins
glycation
turmeric
polyols
streptozotocin
rats
anticarcinogenic activity
Spices
spices

Keywords

  • curcumin
  • anti-oxidant properties
  • anti-inflammatory agents
  • antimicrobial agents
  • anti-carcinogenic activities
  • diabetes
  • diabetic cataract
  • rat experiments

Cite this

Grama, C. N., Suryanarayana, P., Patil, M. A., Raghu, G., Balakrishna, N., Kumar, M. N. V. R., & Reddy, G. B. (2013). Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLOS One, 8(10), [e78217]. https://doi.org/10.1371/journal.pone.0078217
Grama, Charitra N. ; Suryanarayana, Palla ; Patil, Madhoosudan A. ; Raghu, Ganugula ; Balakrishna, Nagalla ; Kumar, M. N. V. Ravi ; Reddy, Geereddy Bhanuprakash. / Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. In: PLOS One. 2013 ; Vol. 8, No. 10.
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Grama, CN, Suryanarayana, P, Patil, MA, Raghu, G, Balakrishna, N, Kumar, MNVR & Reddy, GB 2013, 'Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model' PLOS One, vol. 8, no. 10, e78217. https://doi.org/10.1371/journal.pone.0078217

Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. / Grama, Charitra N.; Suryanarayana, Palla; Patil, Madhoosudan A.; Raghu, Ganugula; Balakrishna, Nagalla; Kumar, M. N. V. Ravi ; Reddy, Geereddy Bhanuprakash.

In: PLOS One, Vol. 8, No. 10, e78217, 14.10.2013.

Research output: Contribution to journalArticle

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Grama CN, Suryanarayana P, Patil MA, Raghu G, Balakrishna N, Kumar MNVR et al. Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLOS One. 2013 Oct 14;8(10). e78217. https://doi.org/10.1371/journal.pone.0078217