Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy

Annette Sorensen, Robert J. Mairs, Lynne Braidwood, Craig Joyce, Joe Conner, Sally Pimlott, S. Moira Brown, Marie Boyd

Research output: Contribution to journalConference Contribution

Abstract

Oncolytic herpes viruses have show promise for the treatment of cancer however it is unlikely that the optimal application of these viruses will be as single therapeutic agents. An alternative strategy would be to utilise these viruses to deliver therapeutic transgenes and enhance their tumour cell killing capacity.
LanguageEnglish
Pages134-135
Number of pages2
JournalMutagenesis
Volume27
Issue number1
DOIs
Publication statusPublished - 2012
Event34th Annual Meeting of the United Kingdom Environmental Mutagen Society - Nottingham, United Kingdom
Duration: 29 Jun 20111 Jul 2011

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Gene transfer
Radiotherapy
Viruses
Oncolytic Viruses
Genes
Neoplasms
Transgenes
Tumors
Therapeutics
Cells

Keywords

  • cancer therapy
  • oncolysis
  • gene transfer

Cite this

Sorensen, Annette ; Mairs, Robert J. ; Braidwood, Lynne ; Joyce, Craig ; Conner, Joe ; Pimlott, Sally ; Brown, S. Moira ; Boyd, Marie. / Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy. In: Mutagenesis. 2012 ; Vol. 27, No. 1. pp. 134-135.
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Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy. / Sorensen, Annette; Mairs, Robert J.; Braidwood, Lynne; Joyce, Craig; Conner, Joe; Pimlott, Sally; Brown, S. Moira; Boyd, Marie.

In: Mutagenesis, Vol. 27, No. 1, 2012, p. 134-135.

Research output: Contribution to journalConference Contribution

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AU - Sorensen, Annette

AU - Mairs, Robert J.

AU - Braidwood, Lynne

AU - Joyce, Craig

AU - Conner, Joe

AU - Pimlott, Sally

AU - Brown, S. Moira

AU - Boyd, Marie

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AB - Oncolytic herpes viruses have show promise for the treatment of cancer however it is unlikely that the optimal application of these viruses will be as single therapeutic agents. An alternative strategy would be to utilise these viruses to deliver therapeutic transgenes and enhance their tumour cell killing capacity.

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KW - oncolysis

KW - gene transfer

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