Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?

Susan Currie, Kimberley Qim, Hui Mum, Sara Campbell, Graeme MacKenzie, Mohd Hanif Mohd Salleh, Dinesh Chellapan, Mayuren Candasamy

Research output: Contribution to journalMeeting abstract

Abstract

The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Gallic Acid
Polyphenols
isoferulic acid

Keywords

  • cardioprotective effects
  • polyphenols
  • cardiomyocytes
  • contractile dysfunction
  • transisoferulic acid
  • gallic acid
  • CaMKII

Cite this

Currie, Susan ; Qim, Kimberley ; Mum, Hui ; Campbell, Sara ; MacKenzie, Graeme ; Mohd Salleh, Mohd Hanif ; Chellapan, Dinesh ; Candasamy, Mayuren. / Effects of trans-isoferulic acid and gallic acid on cardiac contractility : is there a role for CaMKII?. In: International Journal of Molecular Medicine. 2016 ; Vol. 38, No. S1.
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title = "Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?",
abstract = "The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.",
keywords = "cardioprotective effects, polyphenols, cardiomyocytes, contractile dysfunction, transisoferulic acid, gallic acid, CaMKII",
author = "Susan Currie and Kimberley Qim and Hui Mum and Sara Campbell and Graeme MacKenzie and {Mohd Salleh}, {Mohd Hanif} and Dinesh Chellapan and Mayuren Candasamy",
year = "2016",
month = "10",
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language = "English",
volume = "38",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
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Effects of trans-isoferulic acid and gallic acid on cardiac contractility : is there a role for CaMKII? / Currie, Susan; Qim, Kimberley; Mum, Hui ; Campbell, Sara; MacKenzie, Graeme; Mohd Salleh, Mohd Hanif; Chellapan, Dinesh; Candasamy, Mayuren.

In: International Journal of Molecular Medicine, Vol. 38, No. S1, 149, 06.10.2016.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Effects of trans-isoferulic acid and gallic acid on cardiac contractility

T2 - International Journal of Molecular Medicine

AU - Currie, Susan

AU - Qim, Kimberley

AU - Mum, Hui

AU - Campbell, Sara

AU - MacKenzie, Graeme

AU - Mohd Salleh, Mohd Hanif

AU - Chellapan, Dinesh

AU - Candasamy, Mayuren

PY - 2016/10/6

Y1 - 2016/10/6

N2 - The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

AB - The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

KW - cardioprotective effects

KW - polyphenols

KW - cardiomyocytes

KW - contractile dysfunction

KW - transisoferulic acid

KW - gallic acid

KW - CaMKII

UR - https://www.spandidos-publications.com/ijmm

M3 - Meeting abstract

VL - 38

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - S1

M1 - 149

ER -