Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?

Susan Currie; Kimberley Qim; Hui  Mum; Sara Campbell; Graeme MacKenzie; Mohd Hanif Mohd Salleh; Dinesh Chellapan; Mayuren Candasamy

Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?

Susan Currie, Kimberley Qim, Hui Mum, Sara Campbell, Graeme MacKenzie, Mohd Hanif Mohd Salleh, Dinesh Chellapan, Mayuren Candasamy

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference abstract › peer-review

Abstract

The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

Original language	English
Article number	149
Journal	International Journal of Molecular Medicine
Volume	38
Issue number	S1
Publication status	Published - 6 Oct 2016
Event	21st World congress on advances in oncology and 19th international symposium on molecular medicine, Greece - Metropolitan Hotel, Athens, Greece Duration: 6 Oct 2016 → 8 Oct 2016

Keywords

cardioprotective effects
polyphenols
cardiomyocytes
contractile dysfunction
transisoferulic acid
gallic acid
CaMKII

Cite this

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title = "Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?",

abstract = "The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.",

keywords = "cardioprotective effects, polyphenols, cardiomyocytes, contractile dysfunction, transisoferulic acid, gallic acid, CaMKII",

author = "Susan Currie and Kimberley Qim and Hui Mum and Sara Campbell and Graeme MacKenzie and {Mohd Salleh}, {Mohd Hanif} and Dinesh Chellapan and Mayuren Candasamy",

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month = oct,

day = "6",

language = "English",

volume = "38",

journal = "International Journal of Molecular Medicine",

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TY - JOUR

T1 - Effects of trans-isoferulic acid and gallic acid on cardiac contractility

T2 - 21st World congress on advances in oncology and 19th international symposium on molecular medicine, Greece

AU - Currie, Susan

AU - Qim, Kimberley

AU - Mum, Hui

AU - Campbell, Sara

AU - MacKenzie, Graeme

AU - Mohd Salleh, Mohd Hanif

AU - Chellapan, Dinesh

AU - Candasamy, Mayuren

PY - 2016/10/6

Y1 - 2016/10/6

N2 - The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

AB - The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.

KW - cardioprotective effects

KW - polyphenols

KW - cardiomyocytes

KW - contractile dysfunction

KW - transisoferulic acid

KW - gallic acid

KW - CaMKII

UR - https://www.spandidos-publications.com/ijmm

M3 - Conference abstract

SN - 1791-244X

VL - 38

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

IS - S1

M1 - 149

Y2 - 6 October 2016 through 8 October 2016

ER -

Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?

Abstract

Keywords

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