Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII?

Susan Currie, Kimberley Qim, Hui Mum, Sara Campbell, Graeme MacKenzie, Mohd Hanif Mohd Salleh, Dinesh Chellapan, Mayuren Candasamy

Research output: Contribution to journalMeeting abstract

Abstract

The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.
Original languageEnglish
Article number149
JournalInternational Journal of Molecular Medicine
Volume38
Issue numberS1
Publication statusPublished - 6 Oct 2016
Event21st World congress on advances in oncology and 19th international symposium on molecular medicine, Greece - Metropolitan Hotel, Athens, Greece
Duration: 6 Oct 20168 Oct 2016

Keywords

  • cardioprotective effects
  • polyphenols
  • cardiomyocytes
  • contractile dysfunction
  • transisoferulic acid
  • gallic acid
  • CaMKII

Cite this