The cardioprotective effects of polyphenols appear promising: however, their mechanism of action in cardiomycytes remains unknown. CaMKII is an important intracellular modulator of normal cardiac contractility and, when overly activated, can promote contractile dysfunction. This study investigates whether trans-isoferulic acid (TIA) and gallic acid (GA) can alter CaMKII activity in cardiac tissue.
|Journal||International Journal of Molecular Medicine|
|Publication status||Published - 6 Oct 2016|
|Event||21st World congress on advances in oncology and 19th international symposium on molecular medicine, Greece - Metropolitan Hotel, Athens, Greece|
Duration: 6 Oct 2016 → 8 Oct 2016
- cardioprotective effects
- contractile dysfunction
- transisoferulic acid
- gallic acid
Currie, S., Qim, K., Mum, H., Campbell, S., MacKenzie, G., Mohd Salleh, M. H., Chellapan, D., & Candasamy, M. (2016). Effects of trans-isoferulic acid and gallic acid on cardiac contractility: is there a role for CaMKII? International Journal of Molecular Medicine, 38(S1), .