Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

E. Schmidt, S. Ford, N. Dooley, M. Elliot, G. Halbert

Research output: Contribution to journalConference Contribution

40 Citations (Scopus)

Abstract

Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.
Original languageEnglish
Pages (from-to)1428-1429
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number10
Early online date3 Sep 2010
DOIs
Publication statusPublished - Oct 2010
EventUK-PharmSci 2010 – The Science of Medicines - Nottingham, United Kingdom
Duration: 1 Sep 20103 Sep 2010

Fingerprint

Drug Compounding
Mannitol
Fructose
Solubility
Fructose Intolerance
Drug Stability

Keywords

  • P-boronophenylalanine
  • complex-formation
  • monosaccharides
  • solubility

Cite this

@article{f9fdbc640f214e86a18ca86340917f81,
title = "Effects of substituting Fructose by Mannitol in a pharmaceutical formulation",
abstract = "Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.",
keywords = "P-boronophenylalanine, complex-formation, monosaccharides, solubility",
author = "E. Schmidt and S. Ford and N. Dooley and M. Elliot and G. Halbert",
year = "2010",
month = "10",
doi = "10.1111/j.2042-7158.2010.01178.x",
language = "English",
volume = "62",
pages = "1428--1429",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
number = "10",

}

Effects of substituting Fructose by Mannitol in a pharmaceutical formulation. / Schmidt, E.; Ford, S.; Dooley, N.; Elliot, M.; Halbert, G.

In: Journal of Pharmacy and Pharmacology, Vol. 62, No. 10, 10.2010, p. 1428-1429.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

AU - Schmidt, E.

AU - Ford, S.

AU - Dooley, N.

AU - Elliot, M.

AU - Halbert, G.

PY - 2010/10

Y1 - 2010/10

N2 - Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

AB - Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

KW - P-boronophenylalanine

KW - complex-formation

KW - monosaccharides

KW - solubility

U2 - 10.1111/j.2042-7158.2010.01178.x

DO - 10.1111/j.2042-7158.2010.01178.x

M3 - Conference Contribution

VL - 62

SP - 1428

EP - 1429

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 10

ER -