Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

E. Schmidt, S. Ford, N. Dooley, M. Elliot, G. Halbert

Research output: Contribution to journalConference Contribution

42 Citations (Scopus)

Abstract

Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.
Original languageEnglish
Pages (from-to)1428-1429
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number10
Early online date3 Sep 2010
DOIs
Publication statusPublished - Oct 2010
EventUK-PharmSci 2010 – The Science of Medicines - Nottingham, United Kingdom
Duration: 1 Sep 20103 Sep 2010

Keywords

  • P-boronophenylalanine
  • complex-formation
  • monosaccharides
  • solubility

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