Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

E. Schmidt; S. Ford; N. Dooley; M. Elliot; G. Halbert

doi:10.1111/j.2042-7158.2010.01178.x

Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

E. Schmidt, S. Ford, N. Dooley, M. Elliot, G. Halbert

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

52 Citations (Scopus)

Abstract

Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

Original language	English
Pages (from-to)	1428-1429
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	62
Issue number	10
Early online date	3 Sept 2010
DOIs	https://doi.org/10.1111/j.2042-7158.2010.01178.x
Publication status	Published - Oct 2010
Event	UK-PharmSci 2010 – The Science of Medicines - Nottingham, United Kingdom Duration: 1 Sept 2010 → 3 Sept 2010

Keywords

P-boronophenylalanine
complex-formation
monosaccharides
solubility

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10.1111/j.2042-7158.2010.01178.x

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title = "Effects of substituting Fructose by Mannitol in a pharmaceutical formulation",

abstract = "Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.",

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author = "E. Schmidt and S. Ford and N. Dooley and M. Elliot and G. Halbert",

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T1 - Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

AU - Schmidt, E.

AU - Ford, S.

AU - Dooley, N.

AU - Elliot, M.

AU - Halbert, G.

PY - 2010/10

Y1 - 2010/10

N2 - Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

AB - Pharmaceutical formulations can increase the solubility and stability of drug molecules. L-p-10 Boronphenylalanine (BPA) has previously been formulated with Fructose. Here we present a novel BPA formulation with Mannitol resulting in improved kinetic solubility along with the removal of possible Fructose related intolerance reactions.

KW - P-boronophenylalanine

KW - complex-formation

KW - monosaccharides

KW - solubility

U2 - 10.1111/j.2042-7158.2010.01178.x

DO - 10.1111/j.2042-7158.2010.01178.x

M3 - Conference Contribution

SN - 0022-3573

VL - 62

SP - 1428

EP - 1429

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 10

T2 - UK-PharmSci 2010 – The Science of Medicines

Y2 - 1 September 2010 through 3 September 2010

ER -

Effects of substituting Fructose by Mannitol in a pharmaceutical formulation

Abstract

Keywords

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