Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine

M. Skouroliakou, I. Giannopoulou, C. Kostara, J.C. Hannon, Pharmaserve Lilly Greece, Athens, Greece (Funder)

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Weight gain is an established side effect of atypical antipsychotics in patients with severe mental illness (SMI). Previous studies have shown positive effects of nutritional interventions in weight loss. The purpose of this study was to investigate the effects of a nutritional intervention on the body weight and body composition of patients with SMI taking olanzapine in Greece. Methods: Eighty-two patients with SMI treated with olanzapine (22 men, 60 women) and, 58 healthy controls (12 men, 46 women) were followed for 3 mo. All patients with SMI were obese, with an average body mass index of 33.12 +/- 0.74 kg/m(2) and body weight of 94.61 +/- 2.50 kg. A nutritional program was designed for each participant based on anthropometric characteristics, health profile, and dietary needs. Pre- and postintervention anthropometric and body composition measurements were performed. Results: Significant weight loss and fat loss were found in the healthy controls and patients with SMI from baseline to 3 mo (P < 0.05). However, the patients with SMI had a less significant decrease in waist circumference (P < 0.05) compared with healthy controls. The healthy male controls and male patients with SMI demonstrated greater decreases in body weight and waist circumference compared with female participants (P < 0.05). Conclusion: Patients with SMI appear to respond effectively to a nutritional program demonstrating significant decreases in body weight and body composition despite the use of olanzapine. Because gender differences may exist in weight loss, it is possible that gender should be taken into account for a more appropriate treatment of obesity in this population. (C) 2009 Published by Elsevier Inc.
LanguageEnglish
Pages729-735
Number of pages6
JournalNutrition
Volume25
Issue number7-8
DOIs
Publication statusPublished - Jul 2009

Fingerprint

olanzapine
Body Composition
Psychiatry
Body Weight
Weight Loss
Waist Circumference
Greece
Antipsychotic Agents
Weight Gain

Keywords

  • obesity
  • severe mental disease
  • weight loss
  • nutritional intervention

Cite this

Skouroliakou, M., Giannopoulou, I., Kostara, C., Hannon, J. C., & Pharmaserve Lilly Greece, Athens, Greece (Funder) (2009). Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine. Nutrition, 25(7-8), 729-735. https://doi.org/10.1016/j.nut.2008.12.009
Skouroliakou, M. ; Giannopoulou, I. ; Kostara, C. ; Hannon, J.C. ; Pharmaserve Lilly Greece, Athens, Greece (Funder). / Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine. In: Nutrition. 2009 ; Vol. 25, No. 7-8. pp. 729-735.
@article{dcb71cae9720464fba0db723acc094dc,
title = "Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine",
abstract = "Objective: Weight gain is an established side effect of atypical antipsychotics in patients with severe mental illness (SMI). Previous studies have shown positive effects of nutritional interventions in weight loss. The purpose of this study was to investigate the effects of a nutritional intervention on the body weight and body composition of patients with SMI taking olanzapine in Greece. Methods: Eighty-two patients with SMI treated with olanzapine (22 men, 60 women) and, 58 healthy controls (12 men, 46 women) were followed for 3 mo. All patients with SMI were obese, with an average body mass index of 33.12 +/- 0.74 kg/m(2) and body weight of 94.61 +/- 2.50 kg. A nutritional program was designed for each participant based on anthropometric characteristics, health profile, and dietary needs. Pre- and postintervention anthropometric and body composition measurements were performed. Results: Significant weight loss and fat loss were found in the healthy controls and patients with SMI from baseline to 3 mo (P < 0.05). However, the patients with SMI had a less significant decrease in waist circumference (P < 0.05) compared with healthy controls. The healthy male controls and male patients with SMI demonstrated greater decreases in body weight and waist circumference compared with female participants (P < 0.05). Conclusion: Patients with SMI appear to respond effectively to a nutritional program demonstrating significant decreases in body weight and body composition despite the use of olanzapine. Because gender differences may exist in weight loss, it is possible that gender should be taken into account for a more appropriate treatment of obesity in this population. (C) 2009 Published by Elsevier Inc.",
keywords = "obesity, severe mental disease, weight loss, nutritional intervention",
author = "M. Skouroliakou and I. Giannopoulou and C. Kostara and J.C. Hannon and {Pharmaserve Lilly Greece, Athens, Greece (Funder)}",
year = "2009",
month = "7",
doi = "10.1016/j.nut.2008.12.009",
language = "English",
volume = "25",
pages = "729--735",
journal = "Nutrition",
issn = "0899-9007",
number = "7-8",

}

Skouroliakou, M, Giannopoulou, I, Kostara, C, Hannon, JC & Pharmaserve Lilly Greece, Athens, Greece (Funder) 2009, 'Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine' Nutrition, vol. 25, no. 7-8, pp. 729-735. https://doi.org/10.1016/j.nut.2008.12.009

Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine. / Skouroliakou, M.; Giannopoulou, I.; Kostara, C.; Hannon, J.C.; Pharmaserve Lilly Greece, Athens, Greece (Funder).

In: Nutrition, Vol. 25, No. 7-8, 07.2009, p. 729-735.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine

AU - Skouroliakou, M.

AU - Giannopoulou, I.

AU - Kostara, C.

AU - Hannon, J.C.

AU - Pharmaserve Lilly Greece, Athens, Greece (Funder)

PY - 2009/7

Y1 - 2009/7

N2 - Objective: Weight gain is an established side effect of atypical antipsychotics in patients with severe mental illness (SMI). Previous studies have shown positive effects of nutritional interventions in weight loss. The purpose of this study was to investigate the effects of a nutritional intervention on the body weight and body composition of patients with SMI taking olanzapine in Greece. Methods: Eighty-two patients with SMI treated with olanzapine (22 men, 60 women) and, 58 healthy controls (12 men, 46 women) were followed for 3 mo. All patients with SMI were obese, with an average body mass index of 33.12 +/- 0.74 kg/m(2) and body weight of 94.61 +/- 2.50 kg. A nutritional program was designed for each participant based on anthropometric characteristics, health profile, and dietary needs. Pre- and postintervention anthropometric and body composition measurements were performed. Results: Significant weight loss and fat loss were found in the healthy controls and patients with SMI from baseline to 3 mo (P < 0.05). However, the patients with SMI had a less significant decrease in waist circumference (P < 0.05) compared with healthy controls. The healthy male controls and male patients with SMI demonstrated greater decreases in body weight and waist circumference compared with female participants (P < 0.05). Conclusion: Patients with SMI appear to respond effectively to a nutritional program demonstrating significant decreases in body weight and body composition despite the use of olanzapine. Because gender differences may exist in weight loss, it is possible that gender should be taken into account for a more appropriate treatment of obesity in this population. (C) 2009 Published by Elsevier Inc.

AB - Objective: Weight gain is an established side effect of atypical antipsychotics in patients with severe mental illness (SMI). Previous studies have shown positive effects of nutritional interventions in weight loss. The purpose of this study was to investigate the effects of a nutritional intervention on the body weight and body composition of patients with SMI taking olanzapine in Greece. Methods: Eighty-two patients with SMI treated with olanzapine (22 men, 60 women) and, 58 healthy controls (12 men, 46 women) were followed for 3 mo. All patients with SMI were obese, with an average body mass index of 33.12 +/- 0.74 kg/m(2) and body weight of 94.61 +/- 2.50 kg. A nutritional program was designed for each participant based on anthropometric characteristics, health profile, and dietary needs. Pre- and postintervention anthropometric and body composition measurements were performed. Results: Significant weight loss and fat loss were found in the healthy controls and patients with SMI from baseline to 3 mo (P < 0.05). However, the patients with SMI had a less significant decrease in waist circumference (P < 0.05) compared with healthy controls. The healthy male controls and male patients with SMI demonstrated greater decreases in body weight and waist circumference compared with female participants (P < 0.05). Conclusion: Patients with SMI appear to respond effectively to a nutritional program demonstrating significant decreases in body weight and body composition despite the use of olanzapine. Because gender differences may exist in weight loss, it is possible that gender should be taken into account for a more appropriate treatment of obesity in this population. (C) 2009 Published by Elsevier Inc.

KW - obesity

KW - severe mental disease

KW - weight loss

KW - nutritional intervention

UR - http://dx.doi.org/10.1016/j.nut.2008.12.009

U2 - 10.1016/j.nut.2008.12.009

DO - 10.1016/j.nut.2008.12.009

M3 - Article

VL - 25

SP - 729

EP - 735

JO - Nutrition

T2 - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 7-8

ER -

Skouroliakou M, Giannopoulou I, Kostara C, Hannon JC, Pharmaserve Lilly Greece, Athens, Greece (Funder). Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine. Nutrition. 2009 Jul;25(7-8):729-735. https://doi.org/10.1016/j.nut.2008.12.009