Effects of konjac glucomannan hydrolysates on the gut microflora of mice

Abdulmnem A. Elamir, Richard F. Tester, Farage H. Al-Ghazzewi, Hakim Y. Kaal, Amna A. Ghalbon, Najat A. Elmegrahai, John R. Piggott

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose - The aim of this study is to determine the effects of depolymerised mannans and specifically konjac glucomannan hydrolysates (GMH) on the colonic microflora of mice. Blood glucose and cholesterol were also measured. Design/methodology/approach - Two groups (n?=?20) of 12-week old Wister mice were used for a period of 14 weeks. One group (treatment group) were fed diets containing 5 per cent konjac GMH dissolved in drinking water in addition to the control (group) standard diet. Faecal microflora, feed consumption, body weight, blood glucose and cholesterol were determined. Findings - The GMH promoted the growth of anaerobes and lactobacilli in the treatment group where this was statistically, highly significant (P?<?0.001). Also, the hydrolysate was able to reduce highly significantly (P?<?0.001) faecal Clostridium perfringens and Escherichia coli counts. A significant increase in average daily feed consumption (P?<?0.05) and weekly body weight (P?<?0.001) was found for the treatment group. The mean?±?SD (mmol/l) of blood glucose and cholesterol was lower in the treatment group. Originality/value - In addition to modulating the gut microflora, GMH seems to lower the blood glucose and cholesterol in mice. Although this needs to be verified by further studies, GMH could also be a candidate for possible treatment of subjects with high cholesterol and for diabetics.
LanguageEnglish
Pages442-449
Number of pages7
JournalNutrition and Food Science
Volume38
Issue number5
DOIs
Publication statusPublished - 2008

Fingerprint

konjac mannan
hydrolysates
intestinal microorganisms
Cholesterol
Blood Glucose
blood glucose
cholesterol
mice
Body Weight
Diet
Mannans
feed intake
mannans
Clostridium perfringens
Lactobacillus
anaerobes
body weight
Drinking Water
diet
drinking water

Keywords

  • depolymerised mannans
  • konjac glucomannan hydrolysates
  • GMH
  • microflora
  • mice
  • blood glucose
  • cholesterol

Cite this

Elamir, A. A., Tester, R. F., Al-Ghazzewi, F. H., Kaal, H. Y., Ghalbon, A. A., Elmegrahai, N. A., & Piggott, J. R. (2008). Effects of konjac glucomannan hydrolysates on the gut microflora of mice. Nutrition and Food Science, 38(5), 442-449. https://doi.org/10.1108/00346650810906930
Elamir, Abdulmnem A. ; Tester, Richard F. ; Al-Ghazzewi, Farage H. ; Kaal, Hakim Y. ; Ghalbon, Amna A. ; Elmegrahai, Najat A. ; Piggott, John R. / Effects of konjac glucomannan hydrolysates on the gut microflora of mice. In: Nutrition and Food Science. 2008 ; Vol. 38, No. 5. pp. 442-449.
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Elamir, AA, Tester, RF, Al-Ghazzewi, FH, Kaal, HY, Ghalbon, AA, Elmegrahai, NA & Piggott, JR 2008, 'Effects of konjac glucomannan hydrolysates on the gut microflora of mice' Nutrition and Food Science, vol. 38, no. 5, pp. 442-449. https://doi.org/10.1108/00346650810906930

Effects of konjac glucomannan hydrolysates on the gut microflora of mice. / Elamir, Abdulmnem A.; Tester, Richard F.; Al-Ghazzewi, Farage H.; Kaal, Hakim Y.; Ghalbon, Amna A.; Elmegrahai, Najat A.; Piggott, John R.

In: Nutrition and Food Science, Vol. 38, No. 5, 2008, p. 442-449.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of konjac glucomannan hydrolysates on the gut microflora of mice

AU - Elamir, Abdulmnem A.

AU - Tester, Richard F.

AU - Al-Ghazzewi, Farage H.

AU - Kaal, Hakim Y.

AU - Ghalbon, Amna A.

AU - Elmegrahai, Najat A.

AU - Piggott, John R.

PY - 2008

Y1 - 2008

N2 - Purpose - The aim of this study is to determine the effects of depolymerised mannans and specifically konjac glucomannan hydrolysates (GMH) on the colonic microflora of mice. Blood glucose and cholesterol were also measured. Design/methodology/approach - Two groups (n?=?20) of 12-week old Wister mice were used for a period of 14 weeks. One group (treatment group) were fed diets containing 5 per cent konjac GMH dissolved in drinking water in addition to the control (group) standard diet. Faecal microflora, feed consumption, body weight, blood glucose and cholesterol were determined. Findings - The GMH promoted the growth of anaerobes and lactobacilli in the treatment group where this was statistically, highly significant (P?<?0.001). Also, the hydrolysate was able to reduce highly significantly (P?<?0.001) faecal Clostridium perfringens and Escherichia coli counts. A significant increase in average daily feed consumption (P?<?0.05) and weekly body weight (P?<?0.001) was found for the treatment group. The mean?±?SD (mmol/l) of blood glucose and cholesterol was lower in the treatment group. Originality/value - In addition to modulating the gut microflora, GMH seems to lower the blood glucose and cholesterol in mice. Although this needs to be verified by further studies, GMH could also be a candidate for possible treatment of subjects with high cholesterol and for diabetics.

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KW - konjac glucomannan hydrolysates

KW - GMH

KW - microflora

KW - mice

KW - blood glucose

KW - cholesterol

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Elamir AA, Tester RF, Al-Ghazzewi FH, Kaal HY, Ghalbon AA, Elmegrahai NA et al. Effects of konjac glucomannan hydrolysates on the gut microflora of mice. Nutrition and Food Science. 2008;38(5):442-449. https://doi.org/10.1108/00346650810906930