Effects of drinking-water filtration on Cryptosporidium Seroepidemiology, Scotland

Colin N. Ramsay, Adam P. Wagner, Chris Robertson, Huw W. Smith, Kevin G.J. Pollock

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Continuous exposure to low levels of Cryptosporidium oocysts is associated with production of protective antibodies. We investigated prevalence of antibodies against the 27-kDa Cryptosporidium oocyst antigen among blood donors in 2 areas of Scotland supplied by drinking water from different sources with different filtration standards: Glasgow (not filtered) and Dundee (filtered). During 2006–2009, seroprevalence and risk factor data were collected; this period includes 2007, when enhanced filtration was introduced to the Glasgow supply. A serologic response to the 27-kDa antigen was found for ≈75% of donors in the 2 cohorts combined. Mixed regression modeling indicated a 32% step-change reduction in seroprevalence of antibodies against Cryptosporidium among persons in the Glasgow area, which was associated with introduction of enhanced filtration treatment. Removal of Cryptosporidium oocysts from water reduces the risk for waterborne exposure, sporadic infections, and outbreaks. Paradoxically, however, oocyst removal might lower immunity and increase the risk for infection from other sources.
LanguageEnglish
Pages70-76
Number of pages7
JournalEmerging Infectious Diseases
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Cryptosporidium
Oocysts
Scotland
Antibody
Drinking Water
Filtration
Water
Infection
Seroepidemiologic Studies
Immunity
Risk Factors
Antigens
Blood
Antibodies
Person
Regression
Blood Donors
Antibody Formation
Disease Outbreaks
Tissue Donors

Keywords

  • drinking water
  • water filtration
  • cryptosporidium
  • cryptosporidium seroepidemiology

Cite this

Ramsay, Colin N. ; Wagner, Adam P. ; Robertson, Chris ; Smith, Huw W. ; Pollock, Kevin G.J. / Effects of drinking-water filtration on Cryptosporidium Seroepidemiology, Scotland. In: Emerging Infectious Diseases. 2014 ; Vol. 20, No. 1. pp. 70-76.
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abstract = "Continuous exposure to low levels of Cryptosporidium oocysts is associated with production of protective antibodies. We investigated prevalence of antibodies against the 27-kDa Cryptosporidium oocyst antigen among blood donors in 2 areas of Scotland supplied by drinking water from different sources with different filtration standards: Glasgow (not filtered) and Dundee (filtered). During 2006–2009, seroprevalence and risk factor data were collected; this period includes 2007, when enhanced filtration was introduced to the Glasgow supply. A serologic response to the 27-kDa antigen was found for ≈75{\%} of donors in the 2 cohorts combined. Mixed regression modeling indicated a 32{\%} step-change reduction in seroprevalence of antibodies against Cryptosporidium among persons in the Glasgow area, which was associated with introduction of enhanced filtration treatment. Removal of Cryptosporidium oocysts from water reduces the risk for waterborne exposure, sporadic infections, and outbreaks. Paradoxically, however, oocyst removal might lower immunity and increase the risk for infection from other sources.",
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Effects of drinking-water filtration on Cryptosporidium Seroepidemiology, Scotland. / Ramsay, Colin N.; Wagner, Adam P.; Robertson, Chris; Smith, Huw W.; Pollock, Kevin G.J.

In: Emerging Infectious Diseases, Vol. 20, No. 1, 01.2014, p. 70-76.

Research output: Contribution to journalArticle

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