Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results

R Pebody, F Warburton, J Ellis, N Andrews, A Potts, S Cottrell, J Johnston, A Reynolds, R Gunson, C Thompson, M Galiano, C Robertson, D Mullett, N Gallagher, M Sinnathamby, I Yonova, C Moore, J McMenamin, S de Lusignan, M Zambon

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Abstract

In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.
Original languageEnglish
Article number30179
Number of pages8
JournalEurosurveillance
Volume21
Issue number13
DOIs
Publication statusPublished - 31 Mar 2016

Keywords

  • influenza
  • vaccines
  • vaccine effectiveness
  • influenza vaccination
  • influenza surveillance data

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