Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement

Yi-Chieh Chen; Sarra Tiernan-Vandermotten; Leo Lue; Carla Sofia Ferreira; Jan Sefcik; Suresh Thennadil

Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement

Yi-Chieh Chen, Sarra Tiernan-Vandermotten, Leo Lue, Carla Sofia Ferreira, Jan Sefcik, Suresh Thennadil

Chemical And Process Engineering

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Abstract

Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the field of Process Analytical Technology (PAT). This article considers analysis using an innovative spatially and angularly resolved diffuse reflectance measurement (SAR-DRM).

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	European Pharmaceutical Review
Volume	23
Issue number	1
Publication status	Published - 28 Feb 2018

Keywords

particle size distribution
particulate form
particle shape

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Chen-etal-EPR-2018-Effect-of-particle-size-distribution-on-spatially-and-angularly-resolved-diffuseAccepted author manuscript, 788 KB

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title = "Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement",

abstract = "Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the field of Process Analytical Technology (PAT). This article considers analysis using an innovative spatially and angularly resolved diffuse reflectance measurement (SAR-DRM).",

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AU - Chen, Yi-Chieh

AU - Tiernan-Vandermotten, Sarra

AU - Lue, Leo

AU - Ferreira, Carla Sofia

AU - Sefcik, Jan

AU - Thennadil, Suresh

PY - 2018/2/28

Y1 - 2018/2/28

N2 - Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the field of Process Analytical Technology (PAT). This article considers analysis using an innovative spatially and angularly resolved diffuse reflectance measurement (SAR-DRM).

AB - Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the field of Process Analytical Technology (PAT). This article considers analysis using an innovative spatially and angularly resolved diffuse reflectance measurement (SAR-DRM).

KW - particle size distribution

KW - particulate form

KW - particle shape

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M3 - Article

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VL - 23

SP - 34

EP - 37

JO - European Pharmaceutical Review

JF - European Pharmaceutical Review

IS - 1

ER -

Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement

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Keywords

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