Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging

Rachel Sheridan; Javier Cardona; Christos Tachtatzis; Yi-Chieh Chen; Alison Cleary; Naomi E. B. Briggs; Alastair Florence; Robert Atkinson; Craig Michie; Ivan Andonovic; Jan Sefcik

doi:10.1016/j.ces.2021.117188

Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging

Rachel Sheridan
, Javier Cardona
, Christos Tachtatzis
, Yi-Chieh Chen
, Alison Cleary
, Naomi E. B. Briggs
, Alastair Florence
, Robert Atkinson
, Craig Michie
, Ivan Andonovic
, Jan Sefcik

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

53 Downloads (Pure)

Abstract

Conditions that lead to undesired fouling events in oscillatory flow crystallisers are investigated. The moving fluid oscillatory baffled crystalliser is used to mimic the operating conditions of continuous oscillatory baffled crystallisers, while reducing materials and energy consumption. A non-invasive imaging method is deployed to determine fouling induction times as a function of oscillatory flow conditions and supersaturation in crystallisation of glycine and L-glutamic acid from aqueous solutions. Heterogeneous nucleation kinetics are extracted from the distribution of fouling induction times, showing that higher fouling nucleation rates are observed when the frequency and amplitude of the oscillatory flow are increased. Higher oscillatory Reynolds numbers result in increased fluid shear in the crystalliser, promoting heterogeneous nucleation at the glass-solution interface and leading to subsequent fouling. It is therefore essential to consider the dependence of fouling kinetics on operating conditions to
enable rational design of continuous crystallisers that ensure smooth and robust operation.

Original language	English
Article number	117188
Journal	Chemical Engineering Science
Volume	252
Early online date	11 Oct 2021
DOIs	https://doi.org/10.1016/j.ces.2021.117188
Publication status	Published - 28 Apr 2022

Keywords

fouling
crystallisation
oscillatory flow
MFOBC
image analysis

Access to Document

10.1016/j.ces.2021.117188

Sheridan-etal-CES-2021-Effect-of-oscillatory-flow-conditions-on-crystalliser-foulingAccepted author manuscript, 8.48 MBLicence: CC BY-NC-ND 4.0

Intelligent Decision Support Technologies for Continuous Manufacture
Andonovic, I. (Principal Investigator), Bititci, U. (Co-investigator), Florence, A. (Co-investigator), Gachagan, A. (Co-investigator), Johnston, B. (Co-investigator), Marshall, S. (Co-investigator), Michie, C. (Co-investigator), Mulholland, A. (Co-investigator), Nordon, A. (Co-investigator), Sefcik, J. (Co-investigator) & Vasile, M. (Co-investigator)
Bayer Healthcare AG, AstraZeneca UK Limited, Glaxo Smithkline (UK), EPSRC (Engineering and Physical Sciences Research Council), Novartis Pharma AG
1/02/13 → 31/07/18
Project: Research
CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Florence, A. (Principal Investigator), Bititci, U. (Co-investigator), Halbert, G. (Co-investigator), Littlejohn, D. (Co-investigator) & Sefcik, J. (Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/11 → 31/12/16
Project: Research

Data for: "Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging"
Sheridan, R. (Creator), Cardona Amengual, J. (Contributor), Tachtatzis, C. (Contributor), Chen, Y.-C. (Supervisor), Cleary, A. (Contributor), Briggs, N. E. B. (Contributor), Florence, A. (Supervisor), Atkinson, R. (Supervisor), Michie, C. (Supervisor), Andonovic, I. (Supervisor) & Sefcik, J. (Supervisor), University of Strathclyde, 7 Oct 2021
DOI: 10.15129/6d07001a-ad6c-4e0b-bdbb-f8ebf74c142e
Dataset

Cite this

@article{84d8085a6e2e4e0090a4ff110bad7e09,

title = "Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging",

abstract = "Conditions that lead to undesired fouling events in oscillatory flow crystallisers are investigated. The moving fluid oscillatory baffled crystalliser is used to mimic the operating conditions of continuous oscillatory baffled crystallisers, while reducing materials and energy consumption. A non-invasive imaging method is deployed to determine fouling induction times as a function of oscillatory flow conditions and supersaturation in crystallisation of glycine and L-glutamic acid from aqueous solutions. Heterogeneous nucleation kinetics are extracted from the distribution of fouling induction times, showing that higher fouling nucleation rates are observed when the frequency and amplitude of the oscillatory flow are increased. Higher oscillatory Reynolds numbers result in increased fluid shear in the crystalliser, promoting heterogeneous nucleation at the glass-solution interface and leading to subsequent fouling. It is therefore essential to consider the dependence of fouling kinetics on operating conditions to enable rational design of continuous crystallisers that ensure smooth and robust operation.",

keywords = "fouling, crystallisation, oscillatory flow, MFOBC, image analysis",

author = "Rachel Sheridan and Javier Cardona and Christos Tachtatzis and Yi-Chieh Chen and Alison Cleary and Briggs, \{Naomi E. B.\} and Alastair Florence and Robert Atkinson and Craig Michie and Ivan Andonovic and Jan Sefcik",

year = "2022",

month = apr,

day = "28",

doi = "10.1016/j.ces.2021.117188",

language = "English",

volume = "252",

journal = "Chemical Engineering Science ",

issn = "0009-2509",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging

AU - Sheridan, Rachel

AU - Cardona, Javier

AU - Tachtatzis, Christos

AU - Chen, Yi-Chieh

AU - Cleary, Alison

AU - Briggs, Naomi E. B.

AU - Florence, Alastair

AU - Atkinson, Robert

AU - Michie, Craig

AU - Andonovic, Ivan

AU - Sefcik, Jan

PY - 2022/4/28

Y1 - 2022/4/28

N2 - Conditions that lead to undesired fouling events in oscillatory flow crystallisers are investigated. The moving fluid oscillatory baffled crystalliser is used to mimic the operating conditions of continuous oscillatory baffled crystallisers, while reducing materials and energy consumption. A non-invasive imaging method is deployed to determine fouling induction times as a function of oscillatory flow conditions and supersaturation in crystallisation of glycine and L-glutamic acid from aqueous solutions. Heterogeneous nucleation kinetics are extracted from the distribution of fouling induction times, showing that higher fouling nucleation rates are observed when the frequency and amplitude of the oscillatory flow are increased. Higher oscillatory Reynolds numbers result in increased fluid shear in the crystalliser, promoting heterogeneous nucleation at the glass-solution interface and leading to subsequent fouling. It is therefore essential to consider the dependence of fouling kinetics on operating conditions to enable rational design of continuous crystallisers that ensure smooth and robust operation.

AB - Conditions that lead to undesired fouling events in oscillatory flow crystallisers are investigated. The moving fluid oscillatory baffled crystalliser is used to mimic the operating conditions of continuous oscillatory baffled crystallisers, while reducing materials and energy consumption. A non-invasive imaging method is deployed to determine fouling induction times as a function of oscillatory flow conditions and supersaturation in crystallisation of glycine and L-glutamic acid from aqueous solutions. Heterogeneous nucleation kinetics are extracted from the distribution of fouling induction times, showing that higher fouling nucleation rates are observed when the frequency and amplitude of the oscillatory flow are increased. Higher oscillatory Reynolds numbers result in increased fluid shear in the crystalliser, promoting heterogeneous nucleation at the glass-solution interface and leading to subsequent fouling. It is therefore essential to consider the dependence of fouling kinetics on operating conditions to enable rational design of continuous crystallisers that ensure smooth and robust operation.

KW - fouling

KW - crystallisation

KW - oscillatory flow

KW - MFOBC

KW - image analysis

U2 - 10.1016/j.ces.2021.117188

DO - 10.1016/j.ces.2021.117188

M3 - Article

SN - 0009-2509

VL - 252

JO - Chemical Engineering Science

JF - Chemical Engineering Science

M1 - 117188

ER -

Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging

Abstract

Keywords

Access to Document

Fingerprint

Projects

Intelligent Decision Support Technologies for Continuous Manufacture

CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

Datasets

Data for: "Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging"

Cite this