Effect of nanoparticle morphologies on signal strength in photoacoustic sensing

Research output: Contribution to conferenceAbstract

Abstract

Photoacoustic sensing has the potential to probe to greater depths in tissues compared to optical microscopy. The use of plasmonic nanoparticles can further enhance the photoacoustic signal and the resonances of metallic nanoparticles, e.g. gold, can be aligned with commonly used visible and near-IR laser wavelengths. In addition, surface functionalised nanoparticles can be used to target specifc biomolecules. In this work, we report the synthesis of spherical gold nanoparticles with a plasmonic extinction peak at 532 nm and two
sizes of star shaped gold nanoparticles with extinction peaks at 532 nm and 600 nm. The nanoparticles were incorporated into tissue phantoms and the relative performance of the generation of photoacoustic signals from these different nanoparticle morphologies was investigated. At an excitation laser wavelength of 532 nm, we found that the spherical gold nanoparticles generated the greatest photoacoustic response.

Conference

ConferenceOptics + Ultrasound IV
CountryUnited Kingdom
CityGlasgow
Period23/11/17 → …

Fingerprint

Photoacoustic effect
Nanoparticles
Gold
Tissue
Wavelength
Laser excitation
Biomolecules
Stars
Optical microscopy
Lasers

Keywords

  • nanoparticles
  • photoacoustic sensing
  • lasers

Cite this

@conference{ce21c96980444350bf6463975436dbff,
title = "Effect of nanoparticle morphologies on signal strength in photoacoustic sensing",
abstract = "Photoacoustic sensing has the potential to probe to greater depths in tissues compared to optical microscopy. The use of plasmonic nanoparticles can further enhance the photoacoustic signal and the resonances of metallic nanoparticles, e.g. gold, can be aligned with commonly used visible and near-IR laser wavelengths. In addition, surface functionalised nanoparticles can be used to target specifc biomolecules. In this work, we report the synthesis of spherical gold nanoparticles with a plasmonic extinction peak at 532 nm and twosizes of star shaped gold nanoparticles with extinction peaks at 532 nm and 600 nm. The nanoparticles were incorporated into tissue phantoms and the relative performance of the generation of photoacoustic signals from these different nanoparticle morphologies was investigated. At an excitation laser wavelength of 532 nm, we found that the spherical gold nanoparticles generated the greatest photoacoustic response.",
keywords = "nanoparticles, photoacoustic sensing, lasers",
author = "Craig Murdoch and J. Kusch and Flockhart, {G. M. H.} and D. Graham and K. Faulds and D. Uttamchandani",
year = "2017",
month = "11",
day = "23",
language = "English",
note = "Optics + Ultrasound IV ; Conference date: 23-11-2017",

}

Effect of nanoparticle morphologies on signal strength in photoacoustic sensing. / Murdoch, Craig; Kusch, J.; Flockhart, G. M. H.; Graham, D.; Faulds, K.; Uttamchandani, D.

2017. Abstract from Optics + Ultrasound IV, Glasgow, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Effect of nanoparticle morphologies on signal strength in photoacoustic sensing

AU - Murdoch, Craig

AU - Kusch, J.

AU - Flockhart, G. M. H.

AU - Graham, D.

AU - Faulds, K.

AU - Uttamchandani, D.

PY - 2017/11/23

Y1 - 2017/11/23

N2 - Photoacoustic sensing has the potential to probe to greater depths in tissues compared to optical microscopy. The use of plasmonic nanoparticles can further enhance the photoacoustic signal and the resonances of metallic nanoparticles, e.g. gold, can be aligned with commonly used visible and near-IR laser wavelengths. In addition, surface functionalised nanoparticles can be used to target specifc biomolecules. In this work, we report the synthesis of spherical gold nanoparticles with a plasmonic extinction peak at 532 nm and twosizes of star shaped gold nanoparticles with extinction peaks at 532 nm and 600 nm. The nanoparticles were incorporated into tissue phantoms and the relative performance of the generation of photoacoustic signals from these different nanoparticle morphologies was investigated. At an excitation laser wavelength of 532 nm, we found that the spherical gold nanoparticles generated the greatest photoacoustic response.

AB - Photoacoustic sensing has the potential to probe to greater depths in tissues compared to optical microscopy. The use of plasmonic nanoparticles can further enhance the photoacoustic signal and the resonances of metallic nanoparticles, e.g. gold, can be aligned with commonly used visible and near-IR laser wavelengths. In addition, surface functionalised nanoparticles can be used to target specifc biomolecules. In this work, we report the synthesis of spherical gold nanoparticles with a plasmonic extinction peak at 532 nm and twosizes of star shaped gold nanoparticles with extinction peaks at 532 nm and 600 nm. The nanoparticles were incorporated into tissue phantoms and the relative performance of the generation of photoacoustic signals from these different nanoparticle morphologies was investigated. At an excitation laser wavelength of 532 nm, we found that the spherical gold nanoparticles generated the greatest photoacoustic response.

KW - nanoparticles

KW - photoacoustic sensing

KW - lasers

M3 - Abstract

ER -