Effect of geometry on collagen flow in constricted channels for cell delivery

I.M. Syntouka, P. Riches, G. Busby, A. Kazakidi

Research output: Contribution to conferenceAbstract

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Cell therapy has been recently proposed as an effective strategy for the treatment of several neurodegenerative disorders, including Parkinson's disease Natural biomaterials, such as collagen, have been used as scaffolds to facilitate cell deposition, through needle-based delivery. However, despite the protective environment of the scaffold, fluid forces acting on the cells during injection may impact or disrupt their viability [1]. This study aims at developing a novel delivery device for a cell-embedded in situ forming collagen hydrogel. Here, preliminary computational results on constricted channels representing the syringe-needle connection are discussed, providing insight into the effects of the syringe geometry and the needle diameter on collagen flow.
Original languageEnglish
Number of pages1
Publication statusPublished - 29 May 2018
Event31st Scottish Fluid Mechanics Meeting 2018 - University of Aberdeen, Aberdeen, United Kingdom
Duration: 29 May 201829 May 2018


Conference31st Scottish Fluid Mechanics Meeting 2018
Country/TerritoryUnited Kingdom
Internet address


  • cell therapy
  • collagen gel
  • syringe geometry


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