Effect of geometry on collagen flow in constricted channels for cell delivery

Research output: Contribution to conferenceAbstract

Abstract

Cell therapy has been recently proposed as an effective strategy for the treatment of several neurodegenerative disorders, including Parkinson's disease Natural biomaterials, such as collagen, have been used as scaffolds to facilitate cell deposition, through needle-based delivery. However, despite the protective environment of the scaffold, fluid forces acting on the cells during injection may impact or disrupt their viability [1]. This study aims at developing a novel delivery device for a cell-embedded in situ forming collagen hydrogel. Here, preliminary computational results on constricted channels representing the syringe-needle connection are discussed, providing insight into the effects of the syringe geometry and the needle diameter on collagen flow.

Conference

Conference31st Scottish Fluid Mechanics Meeting 2018
CountryUnited Kingdom
CityAberdeen
Period29/05/1829/05/18
Internet address

Fingerprint

Collagen
Needles
Syringes
Geometry
Scaffolds (biology)
Biomaterials
Hydrogels
Scaffolds
Fluids

Keywords

  • cell therapy
  • collagen gel
  • syringe geometry

Cite this

Syntouka, I. M., Riches, P., Busby, G., & Kazakidi, A. (2018). Effect of geometry on collagen flow in constricted channels for cell delivery. Abstract from 31st Scottish Fluid Mechanics Meeting 2018, Aberdeen, United Kingdom.
Syntouka, I.M. ; Riches, P. ; Busby, G. ; Kazakidi, A. / Effect of geometry on collagen flow in constricted channels for cell delivery. Abstract from 31st Scottish Fluid Mechanics Meeting 2018, Aberdeen, United Kingdom.1 p.
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title = "Effect of geometry on collagen flow in constricted channels for cell delivery",
abstract = "Cell therapy has been recently proposed as an effective strategy for the treatment of several neurodegenerative disorders, including Parkinson's disease Natural biomaterials, such as collagen, have been used as scaffolds to facilitate cell deposition, through needle-based delivery. However, despite the protective environment of the scaffold, fluid forces acting on the cells during injection may impact or disrupt their viability [1]. This study aims at developing a novel delivery device for a cell-embedded in situ forming collagen hydrogel. Here, preliminary computational results on constricted channels representing the syringe-needle connection are discussed, providing insight into the effects of the syringe geometry and the needle diameter on collagen flow.",
keywords = "cell therapy, collagen gel, syringe geometry",
author = "I.M. Syntouka and P. Riches and G. Busby and A. Kazakidi",
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note = "31st Scottish Fluid Mechanics Meeting 2018 ; Conference date: 29-05-2018 Through 29-05-2018",
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Syntouka, IM, Riches, P, Busby, G & Kazakidi, A 2018, 'Effect of geometry on collagen flow in constricted channels for cell delivery' 31st Scottish Fluid Mechanics Meeting 2018, Aberdeen, United Kingdom, 29/05/18 - 29/05/18, .

Effect of geometry on collagen flow in constricted channels for cell delivery. / Syntouka, I.M.; Riches, P.; Busby, G.; Kazakidi, A.

2018. Abstract from 31st Scottish Fluid Mechanics Meeting 2018, Aberdeen, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Effect of geometry on collagen flow in constricted channels for cell delivery

AU - Syntouka, I.M.

AU - Riches, P.

AU - Busby, G.

AU - Kazakidi, A.

PY - 2018/5/29

Y1 - 2018/5/29

N2 - Cell therapy has been recently proposed as an effective strategy for the treatment of several neurodegenerative disorders, including Parkinson's disease Natural biomaterials, such as collagen, have been used as scaffolds to facilitate cell deposition, through needle-based delivery. However, despite the protective environment of the scaffold, fluid forces acting on the cells during injection may impact or disrupt their viability [1]. This study aims at developing a novel delivery device for a cell-embedded in situ forming collagen hydrogel. Here, preliminary computational results on constricted channels representing the syringe-needle connection are discussed, providing insight into the effects of the syringe geometry and the needle diameter on collagen flow.

AB - Cell therapy has been recently proposed as an effective strategy for the treatment of several neurodegenerative disorders, including Parkinson's disease Natural biomaterials, such as collagen, have been used as scaffolds to facilitate cell deposition, through needle-based delivery. However, despite the protective environment of the scaffold, fluid forces acting on the cells during injection may impact or disrupt their viability [1]. This study aims at developing a novel delivery device for a cell-embedded in situ forming collagen hydrogel. Here, preliminary computational results on constricted channels representing the syringe-needle connection are discussed, providing insight into the effects of the syringe geometry and the needle diameter on collagen flow.

KW - cell therapy

KW - collagen gel

KW - syringe geometry

UR - https://www.abdn.ac.uk/engineering/events/12948/

M3 - Abstract

ER -

Syntouka IM, Riches P, Busby G, Kazakidi A. Effect of geometry on collagen flow in constricted channels for cell delivery. 2018. Abstract from 31st Scottish Fluid Mechanics Meeting 2018, Aberdeen, United Kingdom.