Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

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Abstract

Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cell
behaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of this
study was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.
Original languageEnglish
Pages (from-to)77
Number of pages1
JournalEuropean Cells and Materials
Volume28
Issue numberS.4
Publication statusPublished - Nov 2014
EventThe 2014 Annual Tissue and Cell Engineering Society (TCES) Meeting - Newcastel university, Newcastle, United Kingdom
Duration: 2 Jul 20144 Jul 2014

Keywords

  • primary hepatocytes
  • rats
  • collagen gel matrices
  • matrix properties

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