Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

Peter E. Agbekoh, Catherine Henderson, Philip E. Riches, M. Helen Grant

Research output: Contribution to journalMeeting abstract

Abstract

Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cell
behaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of this
study was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

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Collagen
Rats
Hepatocytes
Gels
Mechanical properties
Hydrogel
Tissue Engineering
Cell Culture Techniques
Growth
Cell growth
Tissue engineering
Cell culture
Hydrogels
In Vitro Techniques

Keywords

  • primary hepatocytes
  • rats
  • collagen gel matrices
  • matrix properties

Cite this

@article{b772a49229944e5ba75ad3a34695cf20,
title = "Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices",
abstract = "Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.",
keywords = "primary hepatocytes, rats, collagen gel matrices, matrix properties",
author = "Agbekoh, {Peter E.} and Catherine Henderson and Riches, {Philip E.} and Grant, {M. Helen}",
note = "With kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.",
year = "2014",
month = "11",
language = "English",
volume = "28",
pages = "77",
journal = "European Cells and Materials",
issn = "1473-2262",
number = "S.4",

}

Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices. / Agbekoh, Peter E.; Henderson, Catherine; Riches, Philip E.; Grant, M. Helen.

In: European Cells and Materials, Vol. 28, No. S.4, 11.2014, p. 77.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

AU - Agbekoh, Peter E.

AU - Henderson, Catherine

AU - Riches, Philip E.

AU - Grant, M. Helen

N1 - With kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.

PY - 2014/11

Y1 - 2014/11

N2 - Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

AB - Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

KW - primary hepatocytes

KW - rats

KW - collagen gel matrices

KW - matrix properties

UR - http://www.ecmjournal.org/journal/supplements/vol028supp04/vol028supp04.htm

UR - http://www.ecmjournal.org/

M3 - Meeting abstract

VL - 28

SP - 77

JO - European Cells and Materials

T2 - European Cells and Materials

JF - European Cells and Materials

SN - 1473-2262

IS - S.4

ER -