Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

Peter E. Agbekoh; Catherine Henderson; Philip E. Riches; M. Helen Grant

Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

Peter E. Agbekoh, Catherine Henderson, Philip E. Riches, M. Helen Grant

Biomedical Engineering

Research output: Contribution to journal › Meeting abstract › peer-review

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Abstract

Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cell
behaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of this
study was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

Original language	English
Pages (from-to)	77
Number of pages	1
Journal	European Cells and Materials
Volume	28
Issue number	S.4
Publication status	Published - Nov 2014
Event	The 2014 Annual Tissue and Cell Engineering Society (TCES) Meeting - Newcastel university, Newcastle, United Kingdom Duration: 2 Jul 2014 → 4 Jul 2014

Keywords

primary hepatocytes
rats
collagen gel matrices
matrix properties

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title = "Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices",

abstract = "Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.",

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note = "With kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.; The 2014 Annual Tissue and Cell Engineering Society (TCES) Meeting ; Conference date: 02-07-2014 Through 04-07-2014",

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AU - Agbekoh, Peter E.

AU - Henderson, Catherine

AU - Riches, Philip E.

AU - Grant, M. Helen

N1 - With kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.

PY - 2014/11

Y1 - 2014/11

N2 - Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

AB - Collagen gels are widely used as matrices for in vitro cell culture and also for a variety of tissue engineering applications. The mechanical properties of matrices have been shown to be important parameters which greatly influence cellbehaviour. For successful support of long term cell growth and function, it is important for matrices to retain their mechanical integrity during the period of use. The presence of cells has been shown to alter matrix properties. The aim of thisstudy was to investigate the effect of seeding primary hepatocytes on the mechanical properties of collagen hydrogel matrices.

KW - primary hepatocytes

KW - rats

KW - collagen gel matrices

KW - matrix properties

UR - http://www.ecmjournal.org/journal/supplements/vol028supp04/vol028supp04.htm

UR - http://www.ecmjournal.org/

M3 - Meeting abstract

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JO - European Cells and Materials

JF - European Cells and Materials

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T2 - The 2014 Annual Tissue and Cell Engineering Society (TCES) Meeting

Y2 - 2 July 2014 through 4 July 2014

ER -