Effect of combination therapy on immunological progression of Human Immunodeficiency virus at a population level

T. Parpia, G.M. Raab, D.J. Goldberg, G.M. Allardice, J. McMenamin, J. Whitelaw, C. McSharry, R. Potts, R. Herriot

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

There is accumulating evidence from clinical trials and cohort studies that highly active antiretroviral combination therapy is effective at halting immunologic and clinical progression of human immunodeficiency virus (HIV). Its impact at a population level is less well known because the regimes may be difficult to tolerate and compliance poorer. The authors make use of population data for almost all of the HIV-infected people in Scotland in 1997 who were under clinical care and monitor their response to therapy during the first year when these effective treatments became widely available. More than two thirds of the HIV-positive patients were on some form of antiretroviral therapy during the year. The authors show that all treated groups, even those who were on changing regimes, showed net improvement in immunologic status during the year. For the group of patients on triple or quadruple therapy, there was an average increase of more than 100 CD4 cells/mm3 over the year, with other treatment groups showing more modest, but significant, increases.
LanguageEnglish
Pages898-902
Number of pages4
JournalAmerican Journal of Epidemiology
Volume153
Issue number9
DOIs
Publication statusPublished - May 2001

Fingerprint

HIV
Population
Therapeutics
Highly Active Antiretroviral Therapy
Scotland
Compliance
Cohort Studies
Clinical Trials

Keywords

  • acquired immunodeficiency syndrome
  • CD4 lymphocyte count
  • HIV
  • treatment outcome
  • statistics
  • epidemiology

Cite this

Parpia, T., Raab, G. M., Goldberg, D. J., Allardice, G. M., McMenamin, J., Whitelaw, J., ... Herriot, R. (2001). Effect of combination therapy on immunological progression of Human Immunodeficiency virus at a population level. American Journal of Epidemiology, 153(9), 898-902. https://doi.org/10.1093/aje/153.9.898
Parpia, T. ; Raab, G.M. ; Goldberg, D.J. ; Allardice, G.M. ; McMenamin, J. ; Whitelaw, J. ; McSharry, C. ; Potts, R. ; Herriot, R. / Effect of combination therapy on immunological progression of Human Immunodeficiency virus at a population level. In: American Journal of Epidemiology. 2001 ; Vol. 153, No. 9. pp. 898-902.
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Parpia, T, Raab, GM, Goldberg, DJ, Allardice, GM, McMenamin, J, Whitelaw, J, McSharry, C, Potts, R & Herriot, R 2001, 'Effect of combination therapy on immunological progression of Human Immunodeficiency virus at a population level' American Journal of Epidemiology, vol. 153, no. 9, pp. 898-902. https://doi.org/10.1093/aje/153.9.898

Effect of combination therapy on immunological progression of Human Immunodeficiency virus at a population level. / Parpia, T.; Raab, G.M.; Goldberg, D.J.; Allardice, G.M.; McMenamin, J.; Whitelaw, J.; McSharry, C.; Potts, R.; Herriot, R.

In: American Journal of Epidemiology, Vol. 153, No. 9, 05.2001, p. 898-902.

Research output: Contribution to journalArticle

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