Effect of chronic stress during adolescence in prefrontal cortex structure and function

Otávio Augusto de Araújo Costa Folha; Carlomagno Pacheco Bahia; Gisele Priscila Soares de Aguiar; Anderson Manoel Herculano; Nicole Leite Galvão Coelho; Maria Bernardete Cordeiro de Sousa; Victor Kenji Medeiros Shiramizu; Ana Cecília de Menezes Galvão; Walther Augusto de Carvalho; Antonio Pereira

doi:10.1016/j.bbr.2017.02.033

Effect of chronic stress during adolescence in prefrontal cortex structure and function

Otávio Augusto de Araújo Costa Folha, Carlomagno Pacheco Bahia, Gisele Priscila Soares de Aguiar, Anderson Manoel Herculano, Nicole Leite Galvão Coelho, Maria Bernardete Cordeiro de Sousa, Victor Kenji Medeiros Shiramizu, Ana Cecília de Menezes Galvão, Walther Augusto de Carvalho, Antonio Pereira^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent's rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	Behavioural Brain Research
Volume	326
Early online date	24 Feb 2017
DOIs	https://doi.org/10.1016/j.bbr.2017.02.033
Publication status	Published - 30 May 2017

Funding

This study was financially supported by CNPq (476627/2011-7, 483404/2013-6, and 447835/2014-9) and by CAPES.

Keywords

chronic stress
critical period
perineuronal nets
plasticity
pre-frontal cortex

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de Araújo Costa Folha, O. A., Bahia, C. P., de Aguiar, G. P. S., Herculano, A. M., Coelho, N. L. G., de Sousa, M. B. C., Shiramizu, V. K. M., de Menezes Galvão, A. C., de Carvalho, W. A., & Pereira, A. (2017). Effect of chronic stress during adolescence in prefrontal cortex structure and function. Behavioural Brain Research, 326, 44-51. https://doi.org/10.1016/j.bbr.2017.02.033

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abstract = "Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent's rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.",

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AU - Herculano, Anderson Manoel

AU - Coelho, Nicole Leite Galvão

AU - de Sousa, Maria Bernardete Cordeiro

AU - Shiramizu, Victor Kenji Medeiros

AU - de Menezes Galvão, Ana Cecília

AU - de Carvalho, Walther Augusto

AU - Pereira, Antonio

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N2 - Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent's rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.

AB - Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent's rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.

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KW - perineuronal nets

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KW - pre-frontal cortex

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DO - 10.1016/j.bbr.2017.02.033

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VL - 326

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JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Effect of chronic stress during adolescence in prefrontal cortex structure and function

Abstract

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Keywords

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