Abstract
| Language | English |
|---|---|
| Journal | Expert Review of Anti-infective Therapy |
| Publication status | Accepted/In press - 14 Jun 2016 |
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Keywords
- Namibia
- renal function
- creatinine clearance
- combination antiretroviral therapy
- drug utilisation study
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Effect of changing from first- to second- line antiretroviral therapy on renal function : a retrospective study based on data from a single health facility in Namibia. / Kalemeera, Francis; Mbango, Christofina ; Mubita, Mwangana; Naikaku, Esther; Gaida, Razia; Godman, Brian.
In: Expert Review of Anti-infective Therapy, 14.06.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of changing from first- to second- line antiretroviral therapy on renal function
T2 - Expert Review of Anti-infective Therapy
AU - Kalemeera, Francis
AU - Mbango, Christofina
AU - Mubita, Mwangana
AU - Naikaku, Esther
AU - Gaida, Razia
AU - Godman, Brian
PY - 2016/6/14
Y1 - 2016/6/14
N2 - Tenofovir disoproxil fumarate (TDF) and lopinavir/ritonavir (LPV/r) can cause renal impairment with this combination co-administered during second-line combination antiretroviral therapy (cART) potentially associated with greater risk of nephrotoxicity. Objective: Assess effects of second-line cART on renal function. Methods: Retrospective longitudinal study in patients receiving cART. Results: 71 patients received TDF, zidovudine or stavudine, each combined with 3TC/NVP or 3TC/ EFV. Before second-line cART, 46.5% had abnormal kidney function. First-line cART had no relationship with calculated creatinine clearance (CrCl). During second-line cART, more males than females had abnormal renal function and more females experienced increases in CrCl. Calculated CrCl during second-line cART related strongly with CrCl during first-line cART; time spent on cART weak relationship with CrCl. Conclusion: Patients on first-line cART for several years without renal impairment may experience new onset impairment during cART. Patients with pre-existing renal impairment just before switching to second-line cART may experience a further decline.
AB - Tenofovir disoproxil fumarate (TDF) and lopinavir/ritonavir (LPV/r) can cause renal impairment with this combination co-administered during second-line combination antiretroviral therapy (cART) potentially associated with greater risk of nephrotoxicity. Objective: Assess effects of second-line cART on renal function. Methods: Retrospective longitudinal study in patients receiving cART. Results: 71 patients received TDF, zidovudine or stavudine, each combined with 3TC/NVP or 3TC/ EFV. Before second-line cART, 46.5% had abnormal kidney function. First-line cART had no relationship with calculated creatinine clearance (CrCl). During second-line cART, more males than females had abnormal renal function and more females experienced increases in CrCl. Calculated CrCl during second-line cART related strongly with CrCl during first-line cART; time spent on cART weak relationship with CrCl. Conclusion: Patients on first-line cART for several years without renal impairment may experience new onset impairment during cART. Patients with pre-existing renal impairment just before switching to second-line cART may experience a further decline.
KW - Namibia
KW - renal function
KW - creatinine clearance
KW - combination antiretroviral therapy
KW - drug utilisation study
UR - http://www.tandfonline.com/loi/ierz20#.V2QUeqKGwSw
M3 - Article
JO - Expert Review of Anti-infective Therapy
JF - Expert Review of Anti-infective Therapy
SN - 1478-7210
ER -