Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

L Mooney, M Skinner, S. J. Coker, S. Currie

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Abstract

Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.
Original languageEnglish
JournalBritish Journal of Pharmacology
Early online date4 Jun 2015
DOIs
Publication statusPublished - 2015

Keywords

  • cardiac contractility
  • calcium/calmodulin-dependent protein kinase II
  • imatinib
  • sunitinib
  • cardiotoxicity
  • phosphorylation

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