Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

L Mooney, M Skinner, S. J. Coker, S. Currie

Research output: Contribution to journalArticle

11 Citations (Scopus)
119 Downloads (Pure)

Abstract

Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.
Original languageEnglish
JournalBritish Journal of Pharmacology
Early online date4 Jun 2015
DOIs
Publication statusPublished - 2015

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Neoplasms
Phosphotransferases
Pharmaceutical Preparations
sunitinib

Keywords

  • cardiac contractility
  • calcium/calmodulin-dependent protein kinase II
  • imatinib
  • sunitinib
  • cardiotoxicity
  • phosphorylation

Cite this

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Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII. / Mooney, L; Skinner, M; Coker, S. J.; Currie, S.

In: British Journal of Pharmacology, 2015.

Research output: Contribution to journalArticle

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AU - Mooney, L

AU - Skinner, M

AU - Coker, S. J.

AU - Currie, S.

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AB - Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

KW - cardiac contractility

KW - calcium/calmodulin-dependent protein kinase II

KW - imatinib

KW - sunitinib

KW - cardiotoxicity

KW - phosphorylation

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DO - 10.1111/bph.13213

M3 - Article

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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