Economic and epidemiological impact of dengue illness over 16 years from a public health system perspective in Brazil to inform future health policies including the adoption of a dengue vaccine

Isabella Piassi Godói, Leonardo Vinicius Dias da Silva, Abdur Razzaque Sarker, Itamar Megiddo, Alec Morton, Brian Godman, Samantha Alvarez-Madrazo, Marion Bennie, Augusto Afonso Guerra-Júnior

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Introduction: Dengue is a serious global health problem endemic in Brazil. Consequently, our aim was to measure the costs and disease burden of symptomatic dengue infections in Brazil from the perspective of the Brazilian Public Health System (SUS) between 2000 and 2015 using Brazilian public health system databases. Specific age group incidence estimates were used to calculate the disability-adjusted life years (DALYs) to gain a better understanding of the disease burden. Areas covered: SUS spent almost USD159 million and USD10 million to treat dengue and severe dengue, respectively, between 2000-2015. This is principally hospitalization costs with the majority of patients self-treated at home with minor symptoms. The average notification rate for dengue was 273 per 100,000 inhabitants and 3 per 100,000 for severe dengue, with annual DALYs estimates ranging between 72.35 to 6,824.45 during the 16 years. Expert commentary: The epidemiological and morbidity burden associated with dengue is substantial in Brazil, with costs affected by the fact that most patients self-treat at home with these costs not included in SUS. The Brazilian government urgently needs to proactively evaluate the real costs and clinical benefits of any potential dengue vaccination program by the National Immunization Program to guide future decision making.

Original languageEnglish
Pages (from-to)1123–1133
Number of pages11
JournalExpert Review of Vaccines
Issue number12
Early online date10 Nov 2018
Publication statusE-pub ahead of print - 10 Nov 2018


  • burden of disease
  • epidemiology
  • economics
  • dengue
  • public health
  • Brazil

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