Early signalling events of autophagy

Laura E Gallagher, Edmond Y W Chan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Autophagy is a conserved cellular degradative process important for cellular homoeostasis and survival. An early committal step during the initiation of autophagy requires the actions of a protein kinase called ATG1 (autophagy gene 1). In mammalian cells, ATG1 is represented by ULK1 (uncoordinated-51-like kinase 1), which relies on its essential regulatory cofactors mATG13, FIP200 (focal adhesion kinase family-interacting protein 200 kDa) and ATG101. Much evidence indicates that mTORC1 [mechanistic (also known as mammalian) target of rapamycin complex 1] signals downstream to the ULK1 complex to negatively regulate autophagy. In this chapter, we discuss our understanding on how the mTORC1-ULK1 signalling axis drives the initial steps of autophagy induction. We conclude with a summary of our growing appreciation of the additional cellular pathways that interconnect with the core mTORC1-ULK1 signalling module.

LanguageEnglish
Pages1-15
Number of pages15
JournalEssays in Biochemistry
Volume55
Early online date27 Sep 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Autophagy
Phosphotransferases
Genes
Focal Adhesion Protein-Tyrosine Kinases
Protein Kinases
Cells
Homeostasis
mechanistic target of rapamycin complex 1
Proteins

Keywords

  • animals
  • autophagy
  • homeostasis
  • humans
  • signal transduction

Cite this

Gallagher, Laura E ; Chan, Edmond Y W. / Early signalling events of autophagy. In: Essays in Biochemistry. 2013 ; Vol. 55. pp. 1-15.
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Early signalling events of autophagy. / Gallagher, Laura E; Chan, Edmond Y W.

In: Essays in Biochemistry, Vol. 55, 2013, p. 1-15.

Research output: Contribution to journalArticle

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