Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study

Chris J. Packard, Vladimir Bezlyak, Jennifer S. McLean, G. David Batty, Ian Ford, Harry Burns, Jonathan Cavanagh, Kevin A. Deans, Marion Henderson, Agnes McGinty, Keith Millar, Naveed Sattar, Paul G. Shiels, Yoga N. Velupillai, Carol Tannahill

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods: We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results: Associations were observed between father's occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions: Adverse levels of biomarkers of ill health in adults appear to be influenced by father's occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the 'health divide' requires that these life course determinants are taken into account.

LanguageEnglish
Article number42
Number of pages16
JournalBMC Public Health
Volume11
DOIs
Publication statusPublished - 17 Jan 2011

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Carotid Artery Diseases
Cognition
Inflammation
Lung
Biomarkers
Population
Health
Occupations
Fathers
Leg
Chronic Disease
Stroop Test
Phenotype
Verbal Learning
Aptitude
Forced Expiratory Volume
Cell Adhesion Molecules
Health Promotion
Social Class
C-Reactive Protein

Keywords

  • health in adult life
  • socioeconomic deprivation
  • early life adversity

Cite this

Packard, Chris J. ; Bezlyak, Vladimir ; McLean, Jennifer S. ; Batty, G. David ; Ford, Ian ; Burns, Harry ; Cavanagh, Jonathan ; Deans, Kevin A. ; Henderson, Marion ; McGinty, Agnes ; Millar, Keith ; Sattar, Naveed ; Shiels, Paul G. ; Velupillai, Yoga N. ; Tannahill, Carol. / Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance : a cross-sectional, population-based study. In: BMC Public Health. 2011 ; Vol. 11.
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abstract = "Background: Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods: We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results: Associations were observed between father's occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions: Adverse levels of biomarkers of ill health in adults appear to be influenced by father's occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the 'health divide' requires that these life course determinants are taken into account.",
keywords = "health in adult life, socioeconomic deprivation, early life adversity",
author = "Packard, {Chris J.} and Vladimir Bezlyak and McLean, {Jennifer S.} and Batty, {G. David} and Ian Ford and Harry Burns and Jonathan Cavanagh and Deans, {Kevin A.} and Marion Henderson and Agnes McGinty and Keith Millar and Naveed Sattar and Shiels, {Paul G.} and Velupillai, {Yoga N.} and Carol Tannahill",
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Packard, CJ, Bezlyak, V, McLean, JS, Batty, GD, Ford, I, Burns, H, Cavanagh, J, Deans, KA, Henderson, M, McGinty, A, Millar, K, Sattar, N, Shiels, PG, Velupillai, YN & Tannahill, C 2011, 'Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study' BMC Public Health, vol. 11, 42. https://doi.org/10.1186/1471-2458-11-42

Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance : a cross-sectional, population-based study. / Packard, Chris J.; Bezlyak, Vladimir; McLean, Jennifer S.; Batty, G. David; Ford, Ian; Burns, Harry; Cavanagh, Jonathan; Deans, Kevin A.; Henderson, Marion; McGinty, Agnes; Millar, Keith; Sattar, Naveed; Shiels, Paul G.; Velupillai, Yoga N.; Tannahill, Carol.

In: BMC Public Health, Vol. 11, 42, 17.01.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance

T2 - BMC Public Health

AU - Packard, Chris J.

AU - Bezlyak, Vladimir

AU - McLean, Jennifer S.

AU - Batty, G. David

AU - Ford, Ian

AU - Burns, Harry

AU - Cavanagh, Jonathan

AU - Deans, Kevin A.

AU - Henderson, Marion

AU - McGinty, Agnes

AU - Millar, Keith

AU - Sattar, Naveed

AU - Shiels, Paul G.

AU - Velupillai, Yoga N.

AU - Tannahill, Carol

PY - 2011/1/17

Y1 - 2011/1/17

N2 - Background: Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods: We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results: Associations were observed between father's occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions: Adverse levels of biomarkers of ill health in adults appear to be influenced by father's occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the 'health divide' requires that these life course determinants are taken into account.

AB - Background: Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods: We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results: Associations were observed between father's occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions: Adverse levels of biomarkers of ill health in adults appear to be influenced by father's occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the 'health divide' requires that these life course determinants are taken into account.

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KW - socioeconomic deprivation

KW - early life adversity

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