Early detection of amyloid aggregation using intrinsic fluorescence

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Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
Original languageEnglish
Pages (from-to)2249-2252
Number of pages4
JournalBiosensors and Bioelectronics
Volume25
Issue number10
DOIs
Publication statusPublished - 15 Jun 2010

Keywords

  • protein aggregation
  • fluorescence decay
  • Beta amyloid (A beta)
  • alzheimer's disease
  • Tyrosine photophysics

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    • 1 Participation in conference

    Bit's 5th Annual Conference on Protein and Peptide

    Olaf Rolinski (Invited speaker)

    23 Mar 201225 Mar 2012

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