Projects per year
Abstract
Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
Original language | English |
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Pages (from-to) | 2249-2252 |
Number of pages | 4 |
Journal | Biosensors and Bioelectronics |
Volume | 25 |
Issue number | 10 |
DOIs | |
Publication status | Published - 15 Jun 2010 |
Keywords
- protein aggregation
- fluorescence decay
- Beta amyloid (A beta)
- alzheimer's disease
- Tyrosine photophysics
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Dive into the research topics of 'Early detection of amyloid aggregation using intrinsic fluorescence'. Together they form a unique fingerprint.Projects
- 1 Finished
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NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture
Birch, D. (Principal Investigator), Dawson, M. (Co-investigator), Faulds, K. (Co-investigator), Girkin, J. (Co-investigator), Graham, D. (Co-investigator), Martin, R. (Co-investigator), O'Donnell, K. (Co-investigator), Rolinski, O. (Co-investigator), Smith, W. (Co-investigator) & Wynne, K. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/08/08 → 31/01/12
Project: Research
Activities
- 1 Participation in conference
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Bit's 5th Annual Conference on Protein and Peptide
Rolinski, O. (Invited speaker)
23 Mar 2012 → 25 Mar 2012Activity: Participating in or organising an event types › Participation in conference