Early detection of amyloid aggregation using intrinsic fluorescence

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
LanguageEnglish
Pages2249-2252
Number of pages4
JournalBiosensors and Bioelectronics
Volume25
Issue number10
DOIs
Publication statusPublished - 15 Jun 2010

Fingerprint

Amyloid
Agglomeration
Fluorescence
Alzheimer Disease
Tyrosine
Early Diagnosis
Therapeutics

Keywords

  • protein aggregation
  • fluorescence decay
  • Beta amyloid (A beta)
  • alzheimer's disease
  • Tyrosine photophysics

Cite this

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title = "Early detection of amyloid aggregation using intrinsic fluorescence",
abstract = "Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.",
keywords = "protein aggregation, fluorescence decay, Beta amyloid (A beta), alzheimer's disease, Tyrosine photophysics",
author = "O.J. Rolinski and M. Amaro and D.J.S. Birch",
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Early detection of amyloid aggregation using intrinsic fluorescence. / Rolinski, O.J.; Amaro, M.; Birch, D.J.S.

In: Biosensors and Bioelectronics, Vol. 25, No. 10, 15.06.2010, p. 2249-2252.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Rolinski, O.J.

AU - Amaro, M.

AU - Birch, D.J.S.

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AB - Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.

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KW - fluorescence decay

KW - Beta amyloid (A beta)

KW - alzheimer's disease

KW - Tyrosine photophysics

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