Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms

I. V. Timoshkin; J. W. Mackersie; S. J. MacGregor; R. A. Fouracre; J. G. Anderson

doi:10.1109/MODSYM.2004.1433651

Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms

I. V. Timoshkin^*, J. W. Mackersie, S. J. MacGregor, R. A. Fouracre, J. G. Anderson

^*Corresponding author for this work

Electronic And Electrical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

The pulsed electric field (PEF) processing of liquid and pumpable products has attracted significant interest from the pulsed power and bio-science research communities due to the non-thermal mechanisms of inactivation which results in preservation of the original characteristics of the product. Although the PEF process has been studied for several decades, the physical mechanisms of the interaction of pulsed electrical fields with micro-organisms is still not understood fully. The present work is a study of the dynamics of the electrical field in the PEF treatment chamber with dielectric barriers and in the micro-organism's membrane. It was found that the field in the membrane reaches a maximal value which could be two orders of magnitude higher than the original electrical field in the chamber and this value was attained in a time comparable to the Maxwell-Wagner relaxation time, τ_MW. Thus, the optimal duration of the field pulse during the PEF treatment should be equal to the time τ_MW.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Conference Record of the International Power Modulator Symposium and High Voltage Workshop
DOIs	https://doi.org/10.1109/MODSYM.2004.1433651
Publication status	Published - 26 May 2004
Event	2004 IEEE International Power Modulator Conference: 26th International Power Modulator Symposium and 2004 High Voltage Workshop - San Francisco, CA, United States Duration: 23 May 2004 → 26 May 2004

Keywords

biomembranes
voltage
electrode
dielectric liquids
dielectric breakdown
slabs
food technology
organisms
electrostatics
conducting materials
microorganisms
pulsed power supplies
cellular biophysics
bioelectric phenomena

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10.1109/MODSYM.2004.1433651

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title = "Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms",

abstract = "The pulsed electric field (PEF) processing of liquid and pumpable products has attracted significant interest from the pulsed power and bio-science research communities due to the non-thermal mechanisms of inactivation which results in preservation of the original characteristics of the product. Although the PEF process has been studied for several decades, the physical mechanisms of the interaction of pulsed electrical fields with micro-organisms is still not understood fully. The present work is a study of the dynamics of the electrical field in the PEF treatment chamber with dielectric barriers and in the micro-organism's membrane. It was found that the field in the membrane reaches a maximal value which could be two orders of magnitude higher than the original electrical field in the chamber and this value was attained in a time comparable to the Maxwell-Wagner relaxation time, τMW. Thus, the optimal duration of the field pulse during the PEF treatment should be equal to the time τMW.",

keywords = "biomembranes, voltage, electrode, dielectric liquids, dielectric breakdown, slabs, food technology, organisms, electrostatics, conducting materials, microorganisms, pulsed power supplies, cellular biophysics, bioelectric phenomena",

author = "Timoshkin, {I. V.} and Mackersie, {J. W.} and MacGregor, {S. J.} and Fouracre, {R. A.} and Anderson, {J. G.}",

year = "2004",

month = may,

day = "26",

doi = "10.1109/MODSYM.2004.1433651",

language = "English",

pages = "611--614",

note = "2004 IEEE International Power Modulator Conference: 26th International Power Modulator Symposium and 2004 High Voltage Workshop ; Conference date: 23-05-2004 Through 26-05-2004",

}

Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms. / Timoshkin, I. V.; Mackersie, J. W.; MacGregor, S. J. et al.
In: Conference Record of the International Power Modulator Symposium and High Voltage Workshop, 26.05.2004, p. 611-614.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms

AU - Timoshkin, I. V.

AU - Mackersie, J. W.

AU - MacGregor, S. J.

AU - Fouracre, R. A.

AU - Anderson, J. G.

PY - 2004/5/26

Y1 - 2004/5/26

N2 - The pulsed electric field (PEF) processing of liquid and pumpable products has attracted significant interest from the pulsed power and bio-science research communities due to the non-thermal mechanisms of inactivation which results in preservation of the original characteristics of the product. Although the PEF process has been studied for several decades, the physical mechanisms of the interaction of pulsed electrical fields with micro-organisms is still not understood fully. The present work is a study of the dynamics of the electrical field in the PEF treatment chamber with dielectric barriers and in the micro-organism's membrane. It was found that the field in the membrane reaches a maximal value which could be two orders of magnitude higher than the original electrical field in the chamber and this value was attained in a time comparable to the Maxwell-Wagner relaxation time, τMW. Thus, the optimal duration of the field pulse during the PEF treatment should be equal to the time τMW.

AB - The pulsed electric field (PEF) processing of liquid and pumpable products has attracted significant interest from the pulsed power and bio-science research communities due to the non-thermal mechanisms of inactivation which results in preservation of the original characteristics of the product. Although the PEF process has been studied for several decades, the physical mechanisms of the interaction of pulsed electrical fields with micro-organisms is still not understood fully. The present work is a study of the dynamics of the electrical field in the PEF treatment chamber with dielectric barriers and in the micro-organism's membrane. It was found that the field in the membrane reaches a maximal value which could be two orders of magnitude higher than the original electrical field in the chamber and this value was attained in a time comparable to the Maxwell-Wagner relaxation time, τMW. Thus, the optimal duration of the field pulse during the PEF treatment should be equal to the time τMW.

KW - biomembranes

KW - voltage

KW - electrode

KW - dielectric liquids

KW - dielectric breakdown

KW - slabs

KW - food technology

KW - organisms

KW - electrostatics

KW - conducting materials

KW - microorganisms

KW - pulsed power supplies

KW - cellular biophysics

KW - bioelectric phenomena

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DO - 10.1109/MODSYM.2004.1433651

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EP - 614

JO - Conference Record of the International Power Modulator Symposium and High Voltage Workshop

JF - Conference Record of the International Power Modulator Symposium and High Voltage Workshop

T2 - 2004 IEEE International Power Modulator Conference: 26th International Power Modulator Symposium and 2004 High Voltage Workshop

Y2 - 23 May 2004 through 26 May 2004

ER -

Dynamics of the development of an electrical field across cellular membranes - PEF inactivation of micro-organisms

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