A simple water-soluble naphthalenedithiol building block is converted quantitatively into a series of octameric -catenanes, composed of two interlocked molecular squares. When this mixture is re-equilibrated in the presence of an adamantyl ammonium guest, the catenanes disassemble into their macrocyclic components that bind the guest with nanomolar affinity in water.
- molecular science
- molecular squares
- adamantyl ammonium
West, K. R., Ludlow, R. F., Corbett, P. T., Besenius, P., Mansfeld, F. M., Cormack, P. A. G., ... Otto, S. (2008). Dynamic combinatorial discovery of a -catenane and its guest-induced conversion into a molecular square host. Journal of the American Chemical Society, 130(33), 10834–10835. https://doi.org/10.1021/ja801508q