Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters

Roman D. Oparin; Abdenacer Idrissi; Maxim V. Fedorov; Michael G. Kiselev

doi:10.1021/je500456s

Dynamic and static characteristics of drug dissolution in supercritical CO₂ by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters

Roman D. Oparin, Abdenacer Idrissi, Maxim V. Fedorov, Michael G. Kiselev

Research output: Contribution to journal › Article › peer-review

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Abstract

In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO₂ (scCO₂). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10^-6 mol·L^-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO₂ has two steps: (i) "fast" step when the acetaminophen concentration in scCO₂ quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent "slow" step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, "slow" step.

Original language	English
Pages (from-to)	3517-3523
Number of pages	7
Journal	Journal of Chemical and Engineering Data
Volume	59
Issue number	11
Early online date	23 Sep 2014
DOIs	https://doi.org/10.1021/je500456s
Publication status	Published - 13 Nov 2014

Keywords

carbon dioxide
infrared spectroscopy
solubility
acetaminophen solubilities
bioactive substances
dissolution process
lower temperatures
small concentration
solubility properties
static characteristic
supercritical solvents
bioactive molecules
scCO2
mechanisms of solvation
solubility of drugs

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10.1021/je500456s

Oparin-etal-JCED2014-dynamic-and-static-characteristics-of-drug-dissolutionAccepted author manuscript, 1.13 MB

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title = "Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters",

abstract = "In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) {"}fast{"} step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent {"}slow{"} step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, {"}slow{"} step.",

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Dynamic and static characteristics of drug dissolution in supercritical CO₂ by infrared spectroscopy : measurements of acetaminophen solubility in a wide range of state parameters. / Oparin, Roman D.; Idrissi, Abdenacer; Fedorov, Maxim V. et al.

In: Journal of Chemical and Engineering Data, Vol. 59, No. 11, 13.11.2014, p. 3517-3523.

Research output: Contribution to journal › Article › peer-review

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AU - Fedorov, Maxim V.

AU - Kiselev, Michael G.

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AB - In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) "fast" step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent "slow" step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, "slow" step.

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Dynamic and static characteristics of drug dissolution in supercritical CO₂ by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters

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