Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters

Roman D. Oparin, Abdenacer Idrissi, Maxim V. Fedorov, Michael G. Kiselev

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) "fast" step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent "slow" step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, "slow" step.

LanguageEnglish
Pages3517-3523
Number of pages7
JournalJournal of Chemical and Engineering Data
Volume59
Issue number11
Early online date23 Sep 2014
DOIs
Publication statusPublished - 13 Nov 2014

Fingerprint

Acetaminophen
Infrared spectroscopy
Dissolution
Solubility
Pharmaceutical Preparations
Kinetics
Temperature

Keywords

  • carbon dioxide
  • infrared spectroscopy
  • solubility
  • acetaminophen solubilities
  • bioactive substances
  • dissolution process
  • lower temperatures
  • small concentration
  • solubility properties
  • static characteristic
  • supercritical solvents
  • bioactive molecules
  • scCO2
  • mechanisms of solvation
  • solubility of drugs

Cite this

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title = "Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy: measurements of acetaminophen solubility in a wide range of state parameters",
abstract = "In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) {"}fast{"} step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) {\%} of the saturation level and (ii) a subsequent {"}slow{"} step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, {"}slow{"} step.",
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Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy : measurements of acetaminophen solubility in a wide range of state parameters. / Oparin, Roman D.; Idrissi, Abdenacer; Fedorov, Maxim V.; Kiselev, Michael G.

In: Journal of Chemical and Engineering Data, Vol. 59, No. 11, 13.11.2014, p. 3517-3523.

Research output: Contribution to journalArticle

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