Dual task abilities as a possible preclinical marker of Alzheimer's disease in carriers of the E280A presenilin-1 mutation

Sarah E MacPherson, Mario Parra, Sonia Moreno, Francisco Lopera, Sergio Della Sala

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous dual task studies have demonstrated that patients with sporadic Alzheimer's disease (AD) are impaired in their ability to perform two tasks simultaneously compared with healthy controls, despite being able to successfully perform the tasks alone relatively well. Yet, it remains unclear what the earliest clinical manifestation of this dual task coordination deficit is. This study examined dual task abilities in individuals who are at risk of early-onset familial AD due to an E280A presenilin-1 mutation. Thirty-nine carriers of the gene mutation who did not meet the criteria for AD and 29 non-carrier healthy controls were asked to perform digit recall accompanied by a secondary tracking task. Individuals who were carriers of the genetic mutation demonstrated significantly higher dual task costs than healthy non-carriers. Dual task performance was found to be more sensitive to this very early stage of FAD than episodic memory measures. The findings support the notion that a deficit in the coordination mechanism of the central executive may be a pre-clinical marker for the early detection of AD due to the E280A presenilin-1 gene mutation. (JINS, 2011, 18, 1-8).
LanguageEnglish
Pages234-241
Number of pages8
JournalJournal of the International Neuropsychological Society
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 2012

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Presenilin-1
Aptitude
Alzheimer Disease
Mutation
Flavin-Adenine Dinucleotide
Episodic Memory
Task Performance and Analysis
Heterozygote
Genes
Early Diagnosis
Biomarkers
Costs and Cost Analysis

Keywords

  • Alzheimer's disease
  • E280A presenilin-1 mutation
  • dual task abilities

Cite this

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abstract = "Previous dual task studies have demonstrated that patients with sporadic Alzheimer's disease (AD) are impaired in their ability to perform two tasks simultaneously compared with healthy controls, despite being able to successfully perform the tasks alone relatively well. Yet, it remains unclear what the earliest clinical manifestation of this dual task coordination deficit is. This study examined dual task abilities in individuals who are at risk of early-onset familial AD due to an E280A presenilin-1 mutation. Thirty-nine carriers of the gene mutation who did not meet the criteria for AD and 29 non-carrier healthy controls were asked to perform digit recall accompanied by a secondary tracking task. Individuals who were carriers of the genetic mutation demonstrated significantly higher dual task costs than healthy non-carriers. Dual task performance was found to be more sensitive to this very early stage of FAD than episodic memory measures. The findings support the notion that a deficit in the coordination mechanism of the central executive may be a pre-clinical marker for the early detection of AD due to the E280A presenilin-1 gene mutation. (JINS, 2011, 18, 1-8).",
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Dual task abilities as a possible preclinical marker of Alzheimer's disease in carriers of the E280A presenilin-1 mutation. / MacPherson, Sarah E; Parra, Mario; Moreno, Sonia; Lopera, Francisco; Della Sala, Sergio.

In: Journal of the International Neuropsychological Society, Vol. 18, No. 2, 03.2012, p. 234-241.

Research output: Contribution to journalArticle

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