Drug solid solutions - a method for tuning phase transformations

Amit Delori; Pauline Maclure; Rajni M. Bhardwaj; Andrea Johnston; Alastair J. Florence; Oliver B. Sutcliffe; Iain D. H. Oswald

doi:10.1039/c4ce00211c

Drug solid solutions - a method for tuning phase transformations

Amit Delori, Pauline Maclure, Rajni M. Bhardwaj, Andrea Johnston, Alastair J. Florence, Oliver B. Sutcliffe, Iain D. H. Oswald

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

This paper describes a methodology for the modification of phase transition temperatures using (+/-)-4 `-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

Original language	English
Pages (from-to)	5827-5831
Number of pages	5
Journal	CrystEngComm
Volume	16
Issue number	26
Early online date	3 Mar 2014
DOIs	https://doi.org/10.1039/c4ce00211c
Publication status	Published - 14 Jul 2014

Keywords

phase transition temperatures
drug solid solutions
phase transformations

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10.1039/c4ce00211c

Iain Oswald
- iain.oswaldstrath.acuk
- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Reader
Person: Academic

Cite this

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AU - Sutcliffe, Oliver B.

AU - Oswald, Iain D. H.

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AB - This paper describes a methodology for the modification of phase transition temperatures using (+/-)-4 `-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

KW - phase transition temperatures

KW - drug solid solutions

KW - phase transformations

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Drug solid solutions - a method for tuning phase transformations

Abstract

Keywords

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Iain Oswald

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