Drug release kinetics from tablet matrices based upon ethylcellulose ether-derivatives: a comparison between different formulations

V.M. Meidan, G.M. Khan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The present study involved the preparation of ibuprofen-containing controlled release tablets formulated from either the established granular product, Ethocel®Standard Premium, or the novel finely-milled product, Ethocel®Standard FP Premium. The tablets were prepared by either direct compression or wet granulation. The aim was to explore the influence of different parameters on the kinetics and mechanisms of ibuprofen release from the tablets. These parameters were; polymer particle size, polymer molecular weight, drug : polymer ratio, preparation methodology and partial replacement of lactose with the coexcipient-hydroxypropyl methylcellulose (HPMC). The derived drug release data were analyzed with reference to various established mathematical models while the f2-metric technique was used in order to determine profile equivalency. It was found that drug release was mostly modulated by several interactive factors apparently exhibiting crosstalk. Nevertheless, it was possible to identify some simple rules. Incorporation of Ethocel® FP polymers and application of the wet granulation technique facilitated greater efficiency in controlling ibuprofen release behavior from the matrices. Furthermore, drug release profiles could be modulated by partial substitution of the primary excipient with HPMC. Polymer concentrations and particle sizes, rather than viscosity grade, were found to be decisive factors in controlling drug release rates.
LanguageEnglish
Pages627-639
Number of pages12
JournalDrug Development and Industrial Pharmacy
Volume33
Issue number6
DOIs
Publication statusPublished - 2007

Fingerprint

Ether
Tablets
Polymers
Pharmacokinetics
Ibuprofen
Derivatives
Kinetics
Pharmaceutical Preparations
Granulation
Particle Size
Particle size
Excipients
Lactose
Crosstalk
Viscosity
Substitution reactions
Theoretical Models
Molecular Weight
Molecular weight
ethyl cellulose

Keywords

  • ibuprofen
  • ethocel® polymers
  • controlled-release matrices
  • kinetic models
  • release mechanisms
  • pharmacological sciences

Cite this

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title = "Drug release kinetics from tablet matrices based upon ethylcellulose ether-derivatives: a comparison between different formulations",
abstract = "The present study involved the preparation of ibuprofen-containing controlled release tablets formulated from either the established granular product, Ethocel{\circledR}Standard Premium, or the novel finely-milled product, Ethocel{\circledR}Standard FP Premium. The tablets were prepared by either direct compression or wet granulation. The aim was to explore the influence of different parameters on the kinetics and mechanisms of ibuprofen release from the tablets. These parameters were; polymer particle size, polymer molecular weight, drug : polymer ratio, preparation methodology and partial replacement of lactose with the coexcipient-hydroxypropyl methylcellulose (HPMC). The derived drug release data were analyzed with reference to various established mathematical models while the f2-metric technique was used in order to determine profile equivalency. It was found that drug release was mostly modulated by several interactive factors apparently exhibiting crosstalk. Nevertheless, it was possible to identify some simple rules. Incorporation of Ethocel{\circledR} FP polymers and application of the wet granulation technique facilitated greater efficiency in controlling ibuprofen release behavior from the matrices. Furthermore, drug release profiles could be modulated by partial substitution of the primary excipient with HPMC. Polymer concentrations and particle sizes, rather than viscosity grade, were found to be decisive factors in controlling drug release rates.",
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Drug release kinetics from tablet matrices based upon ethylcellulose ether-derivatives: a comparison between different formulations. / Meidan, V.M.; Khan, G.M.

In: Drug Development and Industrial Pharmacy, Vol. 33, No. 6, 2007, p. 627-639.

Research output: Contribution to journalArticle

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