Drug development

lessons from nature (review)

Sunil Mather, Clare Hoskins

Research output: Contribution to journalReview article

Abstract

Natural products have been acknowledged for numerous years as a vital source of active ingredients in therapeutic agents. In particular, the use of active ingredients derived from plants for use in microbial natural products have long been used before the dawn of modern medicine. From ancient times, the efficacy of natural products has been associated with the chemistry, biochemistry and synthetic activities of natural products. Thus, with scientific advancement in modern molecular and cellular biology, analytical chemistry and pharmacology, the unique properties of these natural products are being harnessed in order to exploit the chemical and structural diversity and biodiversity of these types of products in relation to their therapeutic effect. Often, new molecules of interest in drug design units focus on the rearrangement of chemical entities or structural isomers of naturally occurring products in order to generate new molecules; these may be formulated into clinically useful therapies.
Original languageEnglish
Pages (from-to)612-614
Number of pages3
JournalBiomedical Reports
Volume6
Issue number6
DOIs
Publication statusPublished - 14 Dec 2016

Fingerprint

Biological Products
Pharmaceutical Preparations
Cytology
Modern 1601-history
Biochemistry
Molecular biology
Molecules
Drug Design
Biodiversity
Therapeutic Uses
Isomers
Medicine
Cell Biology
Molecular Biology
Pharmacology
Therapeutics
Chemical analysis

Keywords

  • natural products
  • pharmacology
  • active ingredients
  • drug discovery
  • combinatorial chemistry
  • high throughput screening

Cite this

Mather, Sunil ; Hoskins, Clare. / Drug development : lessons from nature (review). In: Biomedical Reports. 2016 ; Vol. 6, No. 6. pp. 612-614.
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Mather, S & Hoskins, C 2016, 'Drug development: lessons from nature (review)', Biomedical Reports, vol. 6, no. 6, pp. 612-614. https://doi.org/10.3892/br.2017.909

Drug development : lessons from nature (review). / Mather, Sunil; Hoskins, Clare.

In: Biomedical Reports, Vol. 6, No. 6, 14.12.2016, p. 612-614.

Research output: Contribution to journalReview article

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N2 - Natural products have been acknowledged for numerous years as a vital source of active ingredients in therapeutic agents. In particular, the use of active ingredients derived from plants for use in microbial natural products have long been used before the dawn of modern medicine. From ancient times, the efficacy of natural products has been associated with the chemistry, biochemistry and synthetic activities of natural products. Thus, with scientific advancement in modern molecular and cellular biology, analytical chemistry and pharmacology, the unique properties of these natural products are being harnessed in order to exploit the chemical and structural diversity and biodiversity of these types of products in relation to their therapeutic effect. Often, new molecules of interest in drug design units focus on the rearrangement of chemical entities or structural isomers of naturally occurring products in order to generate new molecules; these may be formulated into clinically useful therapies.

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KW - combinatorial chemistry

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