Abstract
In this paper we present a general model of drug release from a drug delivery device and the subsequent drug transport in biological tissue. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. The model serves as a useful tool for providing insight into the concurrent effects of the diffusion, convection, solid-liquid transfer and reaction parameters in drug delivery systems.
| Original language | English |
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| Number of pages | 8 |
| Publication status | Published - 10 Jun 2014 |
| Event | 18th European Conference on Mathematics for Industry 2014 - Taormina, Italy Duration: 9 Jun 2014 → 13 Jun 2014 |
Conference
| Conference | 18th European Conference on Mathematics for Industry 2014 |
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| Country/Territory | Italy |
| City | Taormina |
| Period | 9/06/14 → 13/06/14 |
Keywords
- drug delivery
- biological tissues
- two-layer reaction-diffusion-convection model
- drug release
- drug transport
- two-phase mathematical model
- solid-liquid transfer
- diffusion processes
- reaction parameters