Drug and therapeutics committees in Nigeria: evaluation of scope and functionality

Joseph O. Fadare, Olayinka Ogunleye, Reginald Obiako, Samuel Orubu, Okezie Enwere, Adetutu A. Ajemigbitse, Johanna C. Meyer, Ehijie Enato, Amos Massele, Brian Godman, Lars Gustafsson

Research output: Contribution to journalArticle

Abstract

Introduction: Inappropriate use of medicines remains a problem, with consequences including increasing adverse drug reactions (ADRs) and prolonged hospitalizations. The Essential Medicines List and Drug and Therapeutics Committees (DTCs) are accepted initiatives to promote the rational use of medicines. However, little is known about DTC activities in Nigeria, the most populous African country. Areas covered: A cross-sectional questionnaire-based study was conducted among senior pharmacists, consultant physicians and clinical pharmacologists in 12 leading tertiary healthcare facilities across Nigeria. Expert commentary: Six (50%, 6/12) healthcare facilities had existing DTCs with three (50%) having a sub-committee on antimicrobials. 75% had infection control committees, with presence even in centres without DTCs. Chairpersons and secretaries of the DTCs were predominantly physicians (83.3%) and pharmacists (100%) respectively. Hospital formularies were available in five facilities with DTCs, while one facility without a DTC had an Essential Medicines Committee responsible for developing and updating the hospital formulary. The evaluation of ADRs was undertaken by pharmacovigilance units in nine facilities. Overall, DTCs were present in only half of the surveyed facilities and most were performing their statutory functions sub-optimally. The functioning of DTCs can be improved through government directives and mechanisms for continuous evaluation of activities.
LanguageEnglish
JournalExpert Review of Clinical Pharmacology
Publication statusAccepted/In press - 14 Nov 2018

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Pharmacy and Therapeutics Committee
Nigeria
Hospital Formularies
Drug-Related Side Effects and Adverse Reactions
Pharmacists
Physicians
Pharmacovigilance

Keywords

  • rational use of medicines
  • drug and therapeutic committees
  • drug formulary
  • adverse drug reactions
  • Nigeria

Cite this

Fadare, J. O., Ogunleye, O., Obiako, R., Orubu, S., Enwere, O., Ajemigbitse, A. A., ... Gustafsson, L. (Accepted/In press). Drug and therapeutics committees in Nigeria: evaluation of scope and functionality. Expert Review of Clinical Pharmacology.
Fadare, Joseph O. ; Ogunleye, Olayinka ; Obiako, Reginald ; Orubu, Samuel ; Enwere, Okezie ; Ajemigbitse, Adetutu A. ; Meyer, Johanna C. ; Enato, Ehijie ; Massele, Amos ; Godman, Brian ; Gustafsson, Lars. / Drug and therapeutics committees in Nigeria : evaluation of scope and functionality. In: Expert Review of Clinical Pharmacology. 2018.
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Fadare, JO, Ogunleye, O, Obiako, R, Orubu, S, Enwere, O, Ajemigbitse, AA, Meyer, JC, Enato, E, Massele, A, Godman, B & Gustafsson, L 2018, 'Drug and therapeutics committees in Nigeria: evaluation of scope and functionality' Expert Review of Clinical Pharmacology.

Drug and therapeutics committees in Nigeria : evaluation of scope and functionality. / Fadare, Joseph O.; Ogunleye, Olayinka ; Obiako, Reginald; Orubu, Samuel; Enwere, Okezie; Ajemigbitse, Adetutu A.; Meyer, Johanna C.; Enato, Ehijie; Massele, Amos; Godman, Brian; Gustafsson, Lars.

In: Expert Review of Clinical Pharmacology, 14.11.2018.

Research output: Contribution to journalArticle

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T1 - Drug and therapeutics committees in Nigeria

T2 - Expert Review of Clinical Pharmacology

AU - Fadare, Joseph O.

AU - Ogunleye, Olayinka

AU - Obiako, Reginald

AU - Orubu, Samuel

AU - Enwere, Okezie

AU - Ajemigbitse, Adetutu A.

AU - Meyer, Johanna C.

AU - Enato, Ehijie

AU - Massele, Amos

AU - Godman, Brian

AU - Gustafsson, Lars

PY - 2018/11/14

Y1 - 2018/11/14

N2 - Introduction: Inappropriate use of medicines remains a problem, with consequences including increasing adverse drug reactions (ADRs) and prolonged hospitalizations. The Essential Medicines List and Drug and Therapeutics Committees (DTCs) are accepted initiatives to promote the rational use of medicines. However, little is known about DTC activities in Nigeria, the most populous African country. Areas covered: A cross-sectional questionnaire-based study was conducted among senior pharmacists, consultant physicians and clinical pharmacologists in 12 leading tertiary healthcare facilities across Nigeria. Expert commentary: Six (50%, 6/12) healthcare facilities had existing DTCs with three (50%) having a sub-committee on antimicrobials. 75% had infection control committees, with presence even in centres without DTCs. Chairpersons and secretaries of the DTCs were predominantly physicians (83.3%) and pharmacists (100%) respectively. Hospital formularies were available in five facilities with DTCs, while one facility without a DTC had an Essential Medicines Committee responsible for developing and updating the hospital formulary. The evaluation of ADRs was undertaken by pharmacovigilance units in nine facilities. Overall, DTCs were present in only half of the surveyed facilities and most were performing their statutory functions sub-optimally. The functioning of DTCs can be improved through government directives and mechanisms for continuous evaluation of activities.

AB - Introduction: Inappropriate use of medicines remains a problem, with consequences including increasing adverse drug reactions (ADRs) and prolonged hospitalizations. The Essential Medicines List and Drug and Therapeutics Committees (DTCs) are accepted initiatives to promote the rational use of medicines. However, little is known about DTC activities in Nigeria, the most populous African country. Areas covered: A cross-sectional questionnaire-based study was conducted among senior pharmacists, consultant physicians and clinical pharmacologists in 12 leading tertiary healthcare facilities across Nigeria. Expert commentary: Six (50%, 6/12) healthcare facilities had existing DTCs with three (50%) having a sub-committee on antimicrobials. 75% had infection control committees, with presence even in centres without DTCs. Chairpersons and secretaries of the DTCs were predominantly physicians (83.3%) and pharmacists (100%) respectively. Hospital formularies were available in five facilities with DTCs, while one facility without a DTC had an Essential Medicines Committee responsible for developing and updating the hospital formulary. The evaluation of ADRs was undertaken by pharmacovigilance units in nine facilities. Overall, DTCs were present in only half of the surveyed facilities and most were performing their statutory functions sub-optimally. The functioning of DTCs can be improved through government directives and mechanisms for continuous evaluation of activities.

KW - rational use of medicines

KW - drug and therapeutic committees

KW - drug formulary

KW - adverse drug reactions

KW - Nigeria

M3 - Article

JO - Expert Review of Clinical Pharmacology

JF - Expert Review of Clinical Pharmacology

SN - 1751-2433

ER -

Fadare JO, Ogunleye O, Obiako R, Orubu S, Enwere O, Ajemigbitse AA et al. Drug and therapeutics committees in Nigeria: evaluation of scope and functionality. Expert Review of Clinical Pharmacology. 2018 Nov 14.