TY - JOUR
T1 - Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula
AU - Liu, Hongbing
AU - Edrada-Ebel, RuAngelie
AU - Ebel, Rainer
AU - Wang, Yao
AU - Schulz, Barbara
AU - Draeger, Siegfried
AU - Muller, Werner E.G.
AU - Wray, Victor
AU - Lin, Wenhan
AU - Proksch, Peter
PY - 2009
Y1 - 2009
N2 - Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).
AB - Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).
KW - drimane sesquiterpenoids
KW - fungus aspergillus ustus
KW - marine sponge suberites domuncula
KW - drugs
KW - pharmacology
UR - http://dx.doi.org/10.1021/np900220r
U2 - 10.1021/np900220r
DO - 10.1021/np900220r
M3 - Article
SN - 0163-3864
VL - 72
SP - 1585
EP - 1588
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 9
ER -
