Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Hongbing Liu, RuAngelie Edrada-Ebel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E.G. Muller, Victor Wray, Wenhan Lin, Peter Proksch

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53 Citations (Scopus)

Abstract

Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).
Original languageEnglish
Pages (from-to)1585-1588
Number of pages3
JournalJournal of Natural Products
Volume72
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • drimane sesquiterpenoids
  • fungus aspergillus ustus
  • marine sponge suberites domuncula
  • drugs
  • pharmacology

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    Liu, H., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Muller, W. E. G., Wray, V., Lin, W., & Proksch, P. (2009). Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products, 72(9), 1585-1588. https://doi.org/10.1021/np900220r