Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Hongbing Liu; RuAngelie Edrada-Ebel; Rainer Ebel; Yao Wang; Barbara Schulz; Siegfried Draeger; Werner E.G. Muller; Victor Wray; Wenhan Lin; Peter Proksch

doi:10.1021/np900220r

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Hongbing Liu, RuAngelie Edrada-Ebel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E.G. Muller, Victor Wray, Wenhan Lin, Peter Proksch

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).

Original language	English
Pages (from-to)	1585-1588
Number of pages	3
Journal	Journal of Natural Products
Volume	72
Issue number	9
DOIs	https://doi.org/10.1021/np900220r
Publication status	Published - 2009

Keywords

drimane sesquiterpenoids
fungus aspergillus ustus
marine sponge suberites domuncula
drugs
pharmacology

Access to Document

10.1021/np900220r

http://dx.doi.org/10.1021/np900220r

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@article{c6016f26854c4a498ce06c4eae1e58be,

title = "Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula",

abstract = "Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).",

keywords = "drimane sesquiterpenoids, fungus aspergillus ustus, marine sponge suberites domuncula, drugs, pharmacology",

author = "Hongbing Liu and RuAngelie Edrada-Ebel and Rainer Ebel and Yao Wang and Barbara Schulz and Siegfried Draeger and Muller, {Werner E.G.} and Victor Wray and Wenhan Lin and Peter Proksch",

year = "2009",

doi = "10.1021/np900220r",

language = "English",

volume = "72",

pages = "1585--1588",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. / Liu, Hongbing; Edrada-Ebel, RuAngelie; Ebel, Rainer; Wang, Yao; Schulz, Barbara; Draeger, Siegfried; Muller, Werner E.G.; Wray, Victor; Lin, Wenhan; Proksch, Peter.

In: Journal of Natural Products, Vol. 72, No. 9, 2009, p. 1585-1588.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

AU - Liu, Hongbing

AU - Edrada-Ebel, RuAngelie

AU - Ebel, Rainer

AU - Wang, Yao

AU - Schulz, Barbara

AU - Draeger, Siegfried

AU - Muller, Werner E.G.

AU - Wray, Victor

AU - Lin, Wenhan

AU - Proksch, Peter

PY - 2009

Y1 - 2009

N2 - Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).

AB - Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).

KW - drimane sesquiterpenoids

KW - fungus aspergillus ustus

KW - marine sponge suberites domuncula

KW - drugs

KW - pharmacology

UR - http://dx.doi.org/10.1021/np900220r

U2 - 10.1021/np900220r

DO - 10.1021/np900220r

M3 - Article

VL - 72

SP - 1585

EP - 1588

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 9

ER -