Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

J.M. Carlton, R.P. Hirt, J.C. Silva, A.L. Delcher, M. Schatz, Q. Zhao, J.R. Wortmam, S.L. Bidwell, Graham H. Coombs

Research output: Contribution to journalArticle

550 Citations (Scopus)

Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Original languageEnglish
Pages (from-to)207-212
Number of pages5
JournalScience
Volume315
Issue number5809
DOIs
Publication statusPublished - 12 Jan 2007

Keywords

  • tritrichomonas-fetus
  • DNA content
  • eukaryotes
  • cells
  • resistance
  • evolution
  • proteins

Cite this

Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortmam, J. R., Bidwell, S. L., & Coombs, G. H. (2007). Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315(5809), 207-212. https://doi.org/10.1126/science.1132894