Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes

A C Paing, K A McMillan, A F Kirk, A Collier, A Hewitt, S F M Chastin

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Abstract

Abstract Aim To explore the dose?response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. Methods In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m2) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3-min light-intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (?1.0 ± 0.2 mmol/l, P 
LanguageEnglish
JournalDiabetic Medicine
Early online date28 Sep 2018
DOIs
Publication statusE-pub ahead of print - 28 Sep 2018

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Type 2 Diabetes Mellitus
Fasting
Glucose
Walking
Meals
Light

Keywords

  • sedentary time
  • glucose
  • Type 2 diabetes

Cite this

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title = "Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes",
abstract = "Abstract Aim To explore the dose?response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. Methods In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m2) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3-min light-intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (?1.0 ± 0.2 mmol/l, P ",
keywords = "sedentary time, glucose, Type 2 diabetes",
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note = "This is the peer reviewed version of the following article: Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2018). Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes. Diabetic Medicine., which has been published in final form at https://doi.org/10.1111/dme.13829. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.",
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T1 - Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes

AU - Paing, A C

AU - McMillan, K A

AU - Kirk, A F

AU - Collier, A

AU - Hewitt, A

AU - Chastin, S F M

N1 - This is the peer reviewed version of the following article: Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2018). Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes. Diabetic Medicine., which has been published in final form at https://doi.org/10.1111/dme.13829. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

PY - 2018/9/28

Y1 - 2018/9/28

N2 - Abstract Aim To explore the dose?response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. Methods In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m2) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3-min light-intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (?1.0 ± 0.2 mmol/l, P 

AB - Abstract Aim To explore the dose?response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. Methods In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m2) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3-min light-intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (?1.0 ± 0.2 mmol/l, P 

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