Dose-response relationships for Foot and Mouth disease in cattle and sheep

N.P. French, L.A. Kelly, R.D. Kosmider, D. Clancy

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Abstract

The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0·031 with 95% Bayesian credibility intervals (CI) of 0·018-0·052 for cattle, and 0·045 (CI = 0·024-0·080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.
Original languageEnglish
Pages (from-to)325-332
Number of pages7
JournalInfection and Epidemiology
Volume128
DOIs
Publication statusPublished - 2002

Keywords

  • mathematics
  • statistics
  • modelling science
  • biology
  • disease
  • risk assessment

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