Projects per year
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment. Using the Vynckier - Wambersie dose point kernel, a model for dose rate evaluation was created allowing for calculation of absorbed dose values to two cell lines transfected with the noradrenaline transporter (NAT) gene and treated with [(131)I]MIBG. The mean doses required to decrease surviving fractions of UVW/NAT and EJ138/NAT cells, which received medium from [(131)I]MIBG-treated cells, to 25 - 30% were 1.6 and 1.7 Gy respectively. The maximum mean dose rates achieved during [(131)I]MIBG treatment were 0.09 - 0.75 Gy/h for UVW/NAT and 0.07 - 0.78 Gy/h for EJ138/NAT. These were significantly lower than the external beam gamma radiation dose rate of 15 Gy/h. In the case of control lines which were incapable of [(131)I]MIBG uptake the mean absorbed doses following radiopharmaceutical were 0.03 - 0.23 Gy for UVW and 0.03 - 0.32 Gy for EJ138. [(131)I]MIBG treatment for ICCM production elicited a bystander dose-response profile similar to that generated by external beam gamma irradiation but with significantly greater cell death.
|Number of pages||23|
|Journal||Dose-response : a publication of International Hormesis Society|
|Publication status||Published - Jan 2014|
- mathematical modelling
- bystander efects
1/10/15 → 30/09/19
Project: Research - Studentship
1/11/11 → 31/12/11
1/12/10 → 31/05/12
Gamma irradiation and targeted radionuclides enhance the expression of the noradrenaline transporter transgene controlled by the radio-inducible p21WAF1/CIP1 promoterMcCluskey, A. G., Mairs, R. J., Sorensen, A., Robson, T., McCarthy, H. O., Pimlott, S. L., Babich, J. W., Champion, S. & Boyd, M., Mar 2013, In: Radiation Research . 179, 3, p. 282-292 11 p.
Research output: Contribution to journal › Article › peer-review
Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen speciesRae, C., Tesson, M., Babich, J. W., Boyd, M. & Mairs, R. J., 13 Nov 2013, In: EJNMMI Research. 3, 1, 10 p., 73.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile7 Citations (Scopus)79 Downloads (Pure)
Boyd, M., Sorensen, A. & Mairs, R. J., 2013, (Accepted/In press) In: The Journal of Nuclear Medicine. 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile67 Downloads (Pure)