TY - JOUR
T1 - Don't close the book on tocilizumab for the treatment of severe COVID-19 pneumonia - the jury is still out. The Kuwait experience
AU - Al-Shamali, Yousef
AU - Ali, Yaser M.
AU - Al-Shamali, Rawan A.
AU - Al-Melahi, Maryam
AU - Al-Shammari, Farah R.
AU - Alsaber, Ahmad
AU - Al-Adsani, Wasl
PY - 2021/8/24
Y1 - 2021/8/24
N2 - Purpose This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in three of Kuwait's largest public hospitals City. Patients and methods This chart review study examined the benefits of tocilizumab treatment among 127 patients diagnosed with severe coronavirus disease of 2019 (COVID-19) pneumonia. Results 90 of 127 patients (71%) survived. Mortality was highest in the elderly with multiple medical conditions. Conclusion Despite the small sample size and retrospective nature of the work, our findings are consistent with recent studies suggesting tocilizumab administration in patients presenting with severe COVID pneumonia with associated hyperinflammatory features conferred mortality benefit.
AB - Purpose This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in three of Kuwait's largest public hospitals City. Patients and methods This chart review study examined the benefits of tocilizumab treatment among 127 patients diagnosed with severe coronavirus disease of 2019 (COVID-19) pneumonia. Results 90 of 127 patients (71%) survived. Mortality was highest in the elderly with multiple medical conditions. Conclusion Despite the small sample size and retrospective nature of the work, our findings are consistent with recent studies suggesting tocilizumab administration in patients presenting with severe COVID pneumonia with associated hyperinflammatory features conferred mortality benefit.
KW - tocilizumab
KW - severe COVID-19 pneumonia
KW - cytokine Release Storm
KW - hyperinflammatory state
UR - https://journals.plos.org/plosone/
U2 - 10.1371/journal.pone.0254379
DO - 10.1371/journal.pone.0254379
M3 - Article
SN - 1932-6203
VL - 16
JO - PLOS One
JF - PLOS One
IS - 8
M1 - e0254379
ER -