Does the sphingosine 1-phosphate receptor-1 provide a better or worse prognostic outcome for breast cancer patients?

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Recently, Lei et al., (2018) published an article in Cancer Medicine claiming a survival benefit of sphingosine 1-phosphate (S1P) and sphingosine 1-phosphate receptor 1 (S1P1) expression in breast cancer patients. This controversial study opposes the prevailing view concerning the deleterious role of S1P in cancer. This is discussed in depth in the current opinion article.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalFrontiers in Oncology
Issue number417
Publication statusPublished - 27 Sep 2018


  • sphingosine 1-phosphate
  • Sphingosine 1-phosphate receptor 1
  • breast cancer
  • migration
  • growth

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