Experimental studies of the ring-closing metathesis reaction of 1,8-nonadiene and the ROMP reaction of cycloheptene show that the rate of isomerisation is not correlated to the initiation rate of the pre-catalyst, and that the absence of phosphine leads to a greatly increased rate of isomerisation. A range of pre-catalysts and solvents were probed and it is proposed that the isomerisation is mediated by a ruthenium hydride complex; our results are consistent with the rate-determining formation of such a species, which might be trapped in situ by tricyclohexylphosphane.
- ring-closing metathesis reaction
Nelson, D. J., & Percy, J. M. (2014). Does the rate of competing isomerisation during alkene metathesis depend on pre-catalyst initiation rate? Dalton Transactions, 43(12), 4674-4679. https://doi.org/10.1039/c4dt00007b