Abstract
One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .
| Original language | English |
|---|---|
| Pages (from-to) | 766-8 |
| Number of pages | 3 |
| Journal | Biochemical Society Transactions |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1984 |
Keywords
- 3',5'-cyclic-AMP phosphodiesterases
- adenosine diphosphate ribose
- adenosine triphosphate
- adenylate cyclase
- animals
- cyclic AMP
- enzyme activation
- GTP-binding proteins
- glucagon
- guanosine triphosphate
- Insulin
Fingerprint
Dive into the research topics of 'Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver