Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

M D Houslay, A V Wallace, M E Cooper, Nigel Pyne, S R Wilson, C M Heyworth

Research output: Contribution to journalLiterature review

6 Citations (Scopus)

Abstract

One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .
LanguageEnglish
Pages766-8
Number of pages3
JournalBiochemical Society Transactions
Volume12
Issue number5
DOIs
Publication statusPublished - 1984

Fingerprint

Glucagon
GTP-Binding Proteins
Liver
Insulin
Glycogenolysis
Gluconeogenesis
Adenylyl Cyclases
Switches

Keywords

  • 3',5'-cyclic-AMP phosphodiesterases
  • adenosine diphosphate ribose
  • adenosine triphosphate
  • adenylate cyclase
  • animals
  • cyclic AMP
  • enzyme activation
  • GTP-binding proteins
  • glucagon
  • guanosine triphosphate
  • Insulin

Cite this

Houslay, M D ; Wallace, A V ; Cooper, M E ; Pyne, Nigel ; Wilson, S R ; Heyworth, C M. / Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?. In: Biochemical Society Transactions. 1984 ; Vol. 12, No. 5. pp. 766-8.
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abstract = "One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .",
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Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein? / Houslay, M D; Wallace, A V; Cooper, M E; Pyne, Nigel; Wilson, S R; Heyworth, C M.

In: Biochemical Society Transactions, Vol. 12, No. 5, 1984, p. 766-8.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

AU - Houslay, M D

AU - Wallace, A V

AU - Cooper, M E

AU - Pyne, Nigel

AU - Wilson, S R

AU - Heyworth, C M

PY - 1984

Y1 - 1984

N2 - One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .

AB - One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .

KW - 3',5'-cyclic-AMP phosphodiesterases

KW - adenosine diphosphate ribose

KW - adenosine triphosphate

KW - adenylate cyclase

KW - animals

KW - cyclic AMP

KW - enzyme activation

KW - GTP-binding proteins

KW - glucagon

KW - guanosine triphosphate

KW - Insulin

U2 - 10.1042/bst0120766

DO - 10.1042/bst0120766

M3 - Literature review

VL - 12

SP - 766

EP - 768

JO - Biochemical Society Transactions

T2 - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 5

ER -