Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

M D Houslay; A V Wallace; M E Cooper; Nigel Pyne; S R Wilson; C M Heyworth

doi:10.1042/bst0120766

Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

M D Houslay, A V Wallace, M E Cooper, Nigel Pyne, S R Wilson, C M Heyworth

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

8 Citations (Scopus)

Abstract

One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .

Original language	English
Pages (from-to)	766-8
Number of pages	3
Journal	Biochemical Society Transactions
Volume	12
Issue number	5
DOIs	https://doi.org/10.1042/bst0120766
Publication status	Published - 1984

Keywords

3',5'-cyclic-AMP phosphodiesterases
adenosine diphosphate ribose
adenosine triphosphate
adenylate cyclase
animals
cyclic AMP
enzyme activation
GTP-binding proteins
glucagon
guanosine triphosphate
Insulin

Access to Document

10.1042/bst0120766

Cite this

@article{28324be0c4554080b1454d409bffc2b9,

title = "Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?",

abstract = "One of the central features of insulin{\textquoteright}s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .",

keywords = "3',5'-cyclic-AMP phosphodiesterases, adenosine diphosphate ribose, adenosine triphosphate, adenylate cyclase, animals, cyclic AMP, enzyme activation, GTP-binding proteins, glucagon, guanosine triphosphate, Insulin",

author = "Houslay, {M D} and Wallace, {A V} and Cooper, {M E} and Nigel Pyne and Wilson, {S R} and Heyworth, {C M}",

year = "1984",

doi = "10.1042/bst0120766",

language = "English",

volume = "12",

pages = "766--8",

journal = "Biochemical Society Transactions",