DNA nanofabrication by scanning near-field photolithography of oligo (ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation

Shuqing Sun, David G. Thompson, Duncan Graham, Graham J. Leggett

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.

LanguageEnglish
Pages14173-14177
Number of pages5
JournalJournal of Materials Chemistry
Volume21
Issue number37
DOIs
Publication statusPublished - 2011

Fingerprint

Ethylene Glycol
Self assembled monolayers
Photolithography
Ethylene glycol
Nanotechnology
DNA
Scanning
Degradation
Oxidation
Molecules
Photooxidation
Metal nanoparticles
Adsorbates
Aldehydes
Sulfhydryl Compounds
Gold
Nanostructures
Nanoparticles

Keywords

  • self-assembles monolayers
  • protein adsorption
  • probe lithography
  • carbon nanotubes
  • nanostructures
  • fabrication
  • nanoparticles
  • TIC - Bionanotechnology

Cite this

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title = "DNA nanofabrication by scanning near-field photolithography of oligo (ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation",
abstract = "The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.",
keywords = "self-assembles monolayers, protein adsorption, probe lithography, carbon nanotubes, nanostructures, fabrication, nanoparticles, TIC - Bionanotechnology",
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AU - Thompson, David G.

AU - Graham, Duncan

AU - Leggett, Graham J.

PY - 2011

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N2 - The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.

AB - The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.

KW - self-assembles monolayers

KW - protein adsorption

KW - probe lithography

KW - carbon nanotubes

KW - nanostructures

KW - fabrication

KW - nanoparticles

KW - TIC - Bionanotechnology

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