DNA minor groove binders as therapeutic agents

J. M. Withers, G. Padroni, S. M. Pauff, A. W. Clark, S. P. Mackay, G. A. Burley

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)


This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.

Original languageEnglish
Title of host publicationComprehensive Supramolecular Chemistry II
Subtitle of host publicationSupramolecular Medicinal Chemistry and Chemical Biology
EditorsJerry L. Atwood
Place of PublicationAmsterdam
PublisherElsevier Inc.
Number of pages30
ISBN (Print)9780128031995, 9780128031988
Publication statusPublished - 29 Jun 2017


  • anti-infectives
  • DNA
  • gene expression
  • minor groove binding
  • polyamides
  • solid phase synthesis
  • therapeutics


Dive into the research topics of 'DNA minor groove binders as therapeutic agents'. Together they form a unique fingerprint.

Cite this