DNA minor groove binders as therapeutic agents

J. M. Withers; G. Padroni; S. M. Pauff; A. W. Clark; S. P. Mackay; G. A. Burley

doi:10.1016/B978-0-12-409547-2.12561-2

DNA minor groove binders as therapeutic agents

J. M. Withers^*, G. Padroni, S. M. Pauff, A. W. Clark, S. P. Mackay, G. A. Burley

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

Abstract

This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.

Original language	English
Title of host publication	Comprehensive Supramolecular Chemistry II
Subtitle of host publication	Supramolecular Medicinal Chemistry and Chemical Biology
Editors	Jerry L. Atwood
Place of Publication	Amsterdam
Publisher	Elsevier Inc.
Chapter	5.07
Pages	149-178
Number of pages	30
Volume	5
Edition	2nd
ISBN (Print)	9780128031995, 9780128031988
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.12561-2
Publication status	Published - 29 Jun 2017

Keywords

anti-infectives
DNA
gene expression
minor groove binding
polyamides
solid phase synthesis
therapeutics

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10.1016/B978-0-12-409547-2.12561-2

Cite this

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title = "DNA minor groove binders as therapeutic agents",

abstract = "This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.",

keywords = "anti-infectives, DNA, gene expression, minor groove binding, polyamides, solid phase synthesis, therapeutics",

author = "Withers, {J. M.} and G. Padroni and Pauff, {S. M.} and Clark, {A. W.} and Mackay, {S. P.} and Burley, {G. A.}",

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T1 - DNA minor groove binders as therapeutic agents

AU - Withers, J. M.

AU - Padroni, G.

AU - Pauff, S. M.

AU - Clark, A. W.

AU - Mackay, S. P.

AU - Burley, G. A.

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N2 - This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.

AB - This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.

KW - anti-infectives

KW - DNA

KW - gene expression

KW - minor groove binding

KW - polyamides

KW - solid phase synthesis

KW - therapeutics

UR - https://www.sciencedirect.com/referencework/9780128031995/comprehensive-supramolecular-chemistry-ii

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DO - 10.1016/B978-0-12-409547-2.12561-2

M3 - Chapter

AN - SCOPUS:85045088388

SN - 9780128031995

SN - 9780128031988

VL - 5

SP - 149

EP - 178

BT - Comprehensive Supramolecular Chemistry II

A2 - Atwood, Jerry L.

PB - Elsevier Inc.

CY - Amsterdam

ER -

DNA minor groove binders as therapeutic agents

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