DNA duplexes stabilized by modified monomer residues: synthesis and stability

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Abstract

The synthesis of a series of 2'-deoxyuridine analogues modified at the 5-position and a series of 2'-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2'-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied.
Original languageEnglish
Pages (from-to)1131-1138
Number of pages7
JournalJournal of the Chemical Society, Perkin Transactions 1
Volume1998
Issue number6
DOIs
Publication statusPublished - 21 Mar 1998

Keywords

  • substituted pyrimidine nucleosides
  • acid related-compounds
  • antiviral activity
  • oligonucleotides
  • oligodeoxynucleotides
  • 2'-deoxyuridine
  • derivatives
  • agents
  • cells

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