The synthesis of a series of 2'-deoxyuridine analogues modified at the 5-position and a series of 2'-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2'-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied.
|Number of pages||7|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 21 Mar 1998|
- substituted pyrimidine nucleosides
- acid related-compounds
- antiviral activity