Abstract
The high demand in effective and minimally invasive cancer treatments, namely thermal ablation, leads to the demand for real-time multi-dimensional thermometry to evaluate the treatment effectiveness, which can be also assisted by the use of nanoparticles. We report the results of 20-nm gold and magnetic iron oxide nanoparticles-assisted laser ablation on a porcine liver phantom. The experimental set-up consisting of high-scattering nanoparticle-doped fibers was operated by means of a scattering–level multiplexing arrangement and interrogated via optical backscattered reflectometry, together with a solid-state laser diode operating at 980 nm. The multiplexed 2-dimensional fiber arrangement based on nanoparticle-doped fibers allowed an accurate superficial thermal map detected in real-time.
Original language | English |
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Article number | 12593 |
Number of pages | 12 |
Journal | Scientific Reports |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Jul 2020 |
Funding
The research was funded by Nazarbayev University, under Grants SMARTER (Code: 091019CRP2117) and EPICGuide (Code: 240919FD3908). This work was partly supported by ANR Projects Nice-DREAM (ANR-14-CE07-0016-03) and NanoSlim (ANR-17-CE08-0002). This work was partially funded by LASEROPTIMAL@ POLIMI Project (Rif. 2017-2075).
Keywords
- nanoparticles assisted laser ablation
- optical backscattered reflectometry
- solid-state laser diode