Disrupted-in-Schizophrenia-1

W.J. Muir, B.S. Pickard, D.H.R. Blackwood

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.

Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalCurrent Psychiatry Reports
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 2008

Keywords

  • chromosomal abnormalities
  • genes
  • disease risk
  • chromosome translocation
  • psychiatric illness
  • Disrupted-in-Schizophrenia-1
  • DISC1
  • schizophrenia

Cite this